Plexus-Specific Detection of Retinal Vascular Pathologic Conditions with Projection-Resolved OCT Angiography

Rachel C. Patel, Jie Wang, Thomas S. Hwang, Miao Zhang, Simon S. Gao, Mark E. Pennesi, Steven T. Bailey, Brandon J. Lujan, Xiaogang Wang, David J. Wilson, David Huang, Yali Jia

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Purpose: To evaluate the projection-resolved (PR) OCT angiography (OCTA) algorithm in detecting plexus-specific vascular abnormalities in retinal pathologic conditions. Design: Cross-sectional observational clinical study Participants: Patients diagnosed with retinal vascular diseases and healthy volunteers. Methods: Eyes were imaged using an OCT system operating at 840 nm and using the split-spectrum amplitude decorrelation algorithm. A novel algorithm suppressed projection artifacts inherent to OCTA. The volumetric scans were segmented and visualized on different plexuses. Main Outcome Measures: Qualitative observation of vascular abnormalities on both cross-sectional and en face PR-OCTA images. Results: Eight illustrative cases are described. In cases of diabetic retinopathy, retinal vessel occlusion, and retinitis pigmentosa, PR-OCTA detected retinal nonperfusion regions within deeper retinal plexuses not visualized by conventional OCTA. In age-related macular degeneration, cross-sectional PR-OCTA allowed the classification of choroidal neovascularization, and, in a case of retinal angiomatous proliferation, identified a vertical vessel contiguous with the deep capillary plexus. In macular telangiectasia, PR-OCTA detected a diving perifoveal vein and delineated subretinal neovascularization. Conclusions: Application of PR-OCTA promises to improve sensitive, accurate evaluation of individual vascular plexuses in multiple retinal diseases.

Original languageEnglish (US)
Pages (from-to)816-826
Number of pages11
JournalOphthalmology Retina
Issue number8
StatePublished - Aug 2018

ASJC Scopus subject areas

  • Ophthalmology


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