Pontine lesions produce apneusis in the rat

S. F. Morrison, S. L. Cravo, H. M. Wilfehrt

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


Although lesion experiments in the vagotomized cat have indicated that neurons in the parabrachial region of the dorsolateral pons contribute to the mechanisms involved in terminating inspiration, a similar role for pontine structures in the rat has been questioned since pontomedullary transections in the anesthetized rat failed to prolong inspiration. In the present study, lesions of the parabrachial pons of the decerebrate, unanesthetized rat produced an increase in the duration of inspiration to 400% of control and a doubling of the duration of expiration, suggesting a role for this pontine area in the regulation of the timing of the phases of respiration.

Original languageEnglish (US)
Pages (from-to)83-86
Number of pages4
JournalBrain research
Issue number1
StatePublished - Jul 25 1994
Externally publishedYes


  • Decerebration
  • Inspiratory duration
  • Parabrachial complex
  • Phrenic nerve
  • Pons
  • Respiratory timing

ASJC Scopus subject areas

  • General Neuroscience
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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