TY - JOUR
T1 - Postpartum remodeling, lactation, and breast cancer risk
T2 - Summary of a national cancer institute-sponsored workshop
AU - Faupel-Badger, Jessica M.
AU - Arcaro, Kathleen F.
AU - Balkam, Jane J.
AU - Heather Eliassen, A.
AU - Hassiotou, Foteini
AU - Lebrilla, Carlito B.
AU - Michels, Karin B.
AU - Palmer, Julie R.
AU - Schedin, Pepper
AU - Stuebe, Alison M.
AU - Watson, Christine J.
AU - Sherman, Mark E.
N1 - Funding Information:
This work was funded in part by the National Cancer Institute (NCI), Intramural Research Program, and through competitive awards from the Office of Research on Women’s Health (to MES) and Funding to Advance Research on Cancers in Women administrative supplement from the NCI Office of Science Planning and Assessment.
PY - 2013/2/6
Y1 - 2013/2/6
N2 - The pregnancy-lactation cycle (PLC) is a period in which the breast is transformed from a less-developed, nonfunctional organ into a mature, milk-producing gland that has evolved to meet the nutritional, developmental, and immune protection needs of the newborn. Cessation of lactation initiates a process whereby the breast reverts to a resting state until the next pregnancy. Changes during this period permanently alter the morphology and molecular characteristics of the breast (molecular histology) and produce important, yet poorly understood, effects on breast cancer risk. To provide a state-of-the-science summary of this topic, the National Cancer Institute invited a multidisciplinary group of experts to participate in a workshop in Rockville, Maryland, on March 2, 2012. Topics discussed included: 1) the epidemiology of the PLC in relation to breast cancer risk, 2) breast milk as a biospecimen for molecular epidemiological and translational research, and 3) use of animal models to gain mechanistic insights into the effects of the PLC on breast carcinogenesis. This report summarizes conclusions of the workshop, proposes avenues for future research on the PLC and its relationship with breast cancer risk, and identifies opportunities to translate this knowledge to improve breast cancer outcomes.
AB - The pregnancy-lactation cycle (PLC) is a period in which the breast is transformed from a less-developed, nonfunctional organ into a mature, milk-producing gland that has evolved to meet the nutritional, developmental, and immune protection needs of the newborn. Cessation of lactation initiates a process whereby the breast reverts to a resting state until the next pregnancy. Changes during this period permanently alter the morphology and molecular characteristics of the breast (molecular histology) and produce important, yet poorly understood, effects on breast cancer risk. To provide a state-of-the-science summary of this topic, the National Cancer Institute invited a multidisciplinary group of experts to participate in a workshop in Rockville, Maryland, on March 2, 2012. Topics discussed included: 1) the epidemiology of the PLC in relation to breast cancer risk, 2) breast milk as a biospecimen for molecular epidemiological and translational research, and 3) use of animal models to gain mechanistic insights into the effects of the PLC on breast carcinogenesis. This report summarizes conclusions of the workshop, proposes avenues for future research on the PLC and its relationship with breast cancer risk, and identifies opportunities to translate this knowledge to improve breast cancer outcomes.
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U2 - 10.1093/jnci/djs505
DO - 10.1093/jnci/djs505
M3 - Review article
C2 - 23264680
AN - SCOPUS:84873605440
SN - 0027-8874
VL - 105
SP - 166
EP - 174
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
IS - 3
ER -