Practical management of ocular surface disease in patients with atopic dermatitis, with a focus on conjunctivitis: A review

Vivian Y. Shi; Winston Chamberlain; Elaine Siegfried; Cheryl Kraff-Cooper; Kenneth Beckman; Peter Lio; Amy S. Paller; Eric Simpson

doi:10.1016/j.jaad.2023.01.043

Practical management of ocular surface disease in patients with atopic dermatitis, with a focus on conjunctivitis: A review

Vivian Y. Shi, Winston Chamberlain, Elaine Siegfried, Cheryl Kraff-Cooper, Kenneth Beckman, Peter Lio, Amy S. Paller, Eric Simpson

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

Atopic dermatitis (AD) is a chronic inflammatory skin disease that can significantly decrease quality of life. AD is commonly associated with comorbidities including ocular surface disease (OSD). Conjunctivitis is the most common OSD associated with AD and can increase in incidence with use of monoclonal antibody biologics that target the type 2 inflammatory pathway. The objective of this review is to raise awareness of comorbid OSD in AD patients that dermatologists may encounter, with a focus on conjunctivitis, and equip dermatologists to address mild ocular concerns. We provide background on the subtypes and pathogenesis of comorbid OSD in AD patients and describe OSD associated with type 2 inflammation-inhibiting AD biologics. We also discuss screening and diagnosis, recommended treatment options for dermatologists, and when to refer to an eye care specialist. This multispecialty approach aims to support the overall health of AD patients and provide optimal patient care.

Original language	English (US)
Pages (from-to)	309-315
Number of pages	7
Journal	Journal of the American Academy of Dermatology
Volume	89
Issue number	2
DOIs	https://doi.org/10.1016/j.jaad.2023.01.043
State	Published - Aug 2023

Keywords

atopic dermatitis
biologics
conjunctivitis
eczema
multispecialty care
ocular surface disease

ASJC Scopus subject areas

Dermatology

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10.1016/j.jaad.2023.01.043

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title = "Practical management of ocular surface disease in patients with atopic dermatitis, with a focus on conjunctivitis: A review",

abstract = "Atopic dermatitis (AD) is a chronic inflammatory skin disease that can significantly decrease quality of life. AD is commonly associated with comorbidities including ocular surface disease (OSD). Conjunctivitis is the most common OSD associated with AD and can increase in incidence with use of monoclonal antibody biologics that target the type 2 inflammatory pathway. The objective of this review is to raise awareness of comorbid OSD in AD patients that dermatologists may encounter, with a focus on conjunctivitis, and equip dermatologists to address mild ocular concerns. We provide background on the subtypes and pathogenesis of comorbid OSD in AD patients and describe OSD associated with type 2 inflammation-inhibiting AD biologics. We also discuss screening and diagnosis, recommended treatment options for dermatologists, and when to refer to an eye care specialist. This multispecialty approach aims to support the overall health of AD patients and provide optimal patient care.",

keywords = "atopic dermatitis, biologics, conjunctivitis, eczema, multispecialty care, ocular surface disease",

author = "Shi, {Vivian Y.} and Winston Chamberlain and Elaine Siegfried and Cheryl Kraff-Cooper and Kenneth Beckman and Peter Lio and Paller, {Amy S.} and Eric Simpson",

note = "Publisher Copyright: {\textcopyright} 2023 American Academy of Dermatology, Inc.",

year = "2023",

month = aug,

doi = "10.1016/j.jaad.2023.01.043",

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T2 - A review

AU - Shi, Vivian Y.

AU - Chamberlain, Winston

AU - Siegfried, Elaine

AU - Kraff-Cooper, Cheryl

AU - Beckman, Kenneth

AU - Lio, Peter

AU - Paller, Amy S.

AU - Simpson, Eric

PY - 2023/8

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N2 - Atopic dermatitis (AD) is a chronic inflammatory skin disease that can significantly decrease quality of life. AD is commonly associated with comorbidities including ocular surface disease (OSD). Conjunctivitis is the most common OSD associated with AD and can increase in incidence with use of monoclonal antibody biologics that target the type 2 inflammatory pathway. The objective of this review is to raise awareness of comorbid OSD in AD patients that dermatologists may encounter, with a focus on conjunctivitis, and equip dermatologists to address mild ocular concerns. We provide background on the subtypes and pathogenesis of comorbid OSD in AD patients and describe OSD associated with type 2 inflammation-inhibiting AD biologics. We also discuss screening and diagnosis, recommended treatment options for dermatologists, and when to refer to an eye care specialist. This multispecialty approach aims to support the overall health of AD patients and provide optimal patient care.

AB - Atopic dermatitis (AD) is a chronic inflammatory skin disease that can significantly decrease quality of life. AD is commonly associated with comorbidities including ocular surface disease (OSD). Conjunctivitis is the most common OSD associated with AD and can increase in incidence with use of monoclonal antibody biologics that target the type 2 inflammatory pathway. The objective of this review is to raise awareness of comorbid OSD in AD patients that dermatologists may encounter, with a focus on conjunctivitis, and equip dermatologists to address mild ocular concerns. We provide background on the subtypes and pathogenesis of comorbid OSD in AD patients and describe OSD associated with type 2 inflammation-inhibiting AD biologics. We also discuss screening and diagnosis, recommended treatment options for dermatologists, and when to refer to an eye care specialist. This multispecialty approach aims to support the overall health of AD patients and provide optimal patient care.

KW - atopic dermatitis

KW - biologics

KW - conjunctivitis

KW - eczema

KW - multispecialty care

KW - ocular surface disease

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Practical management of ocular surface disease in patients with atopic dermatitis, with a focus on conjunctivitis: A review

Abstract

Keywords

ASJC Scopus subject areas

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