TY - JOUR
T1 - Predicting children's quality of life in an asthma clinical trial
T2 - What do children's reports tell us?
AU - Annett, Robert D.
AU - Bender, Bruce G.
AU - Lapidus, Jodi
AU - DuHamel, Thomas R.
AU - Lincoln, Alan
N1 - Funding Information:
Supported by a grant from the Agency for Health Care Policy and Research (R03 HS09123-01) and a contract from the Department of Health and Human Services, National Heart, Lung, and Blood Institute (NHLBI-HR-90-13). Children’s Asthma Management Program is supported by contracts NO1-HR-16044, 16045, 16046, 16047, 16048, 16049, 16050, 16051, and 16052 from the National Heart Lung and Blood Institute. Submitted for publication Jan 12, 2001; revision received June 20, 2001; accepted Aug 9, 2001. Reprint requests: Robert D. Annett, PhD, Department of Pediatrics, University of New Mexico Health Sciences Center, Albuquerque, NM, 87131-5311. Copyright © 2001 by Mosby, Inc. 0022-3476/2001/$35.00 + 0 9/21/119444 doi:10.1067/mpd.2001.119444
PY - 2001
Y1 - 2001
N2 - Objective: To define predictors of disease-specific quality of life (QOL) and the relationship between asthma symptoms and disease-specific QOL. Study design: Three hundred thirty-nine children participated at 4 of 8 Childhood Asthma Management Program clinical centers. Included in the analyses were 2 weeks of asthma symptom data, child-reported health status, and QOL scores from the Pediatric Asthma Quality of Life Questionnaire. Data were obtained 12 months after randomization into the Childhood Asthma Management Program. Results: Children were rated at baseline as having "moderate" asthma (63%) and "mild" asthma (37%). QOL scores were correlated with the child-reported anxiety measures. Factor analysis of the QOL measure resulted in 2 factors. Stepwise multiple regression indicated that the strongest independent predictors of QOL were the child's anxiety level, age, sex, and a measure of the child's tendency to minimize or exaggerate symptoms. Conclusions: Children had few asthma symptoms in the 2 weeks before their 12-month follow-up clinic visit and a generally positive QOL, suggesting that mild-to-moderate asthma does not significantly impair QOL. A child's QOL was predicted primarily by their level of anxiety.
AB - Objective: To define predictors of disease-specific quality of life (QOL) and the relationship between asthma symptoms and disease-specific QOL. Study design: Three hundred thirty-nine children participated at 4 of 8 Childhood Asthma Management Program clinical centers. Included in the analyses were 2 weeks of asthma symptom data, child-reported health status, and QOL scores from the Pediatric Asthma Quality of Life Questionnaire. Data were obtained 12 months after randomization into the Childhood Asthma Management Program. Results: Children were rated at baseline as having "moderate" asthma (63%) and "mild" asthma (37%). QOL scores were correlated with the child-reported anxiety measures. Factor analysis of the QOL measure resulted in 2 factors. Stepwise multiple regression indicated that the strongest independent predictors of QOL were the child's anxiety level, age, sex, and a measure of the child's tendency to minimize or exaggerate symptoms. Conclusions: Children had few asthma symptoms in the 2 weeks before their 12-month follow-up clinic visit and a generally positive QOL, suggesting that mild-to-moderate asthma does not significantly impair QOL. A child's QOL was predicted primarily by their level of anxiety.
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U2 - 10.1067/mpd.2001.119444
DO - 10.1067/mpd.2001.119444
M3 - Article
C2 - 11743513
AN - SCOPUS:0035666479
SN - 0022-3476
VL - 139
SP - 854
EP - 861
JO - Journal of Pediatrics
JF - Journal of Pediatrics
IS - 6
ER -