Predicting children's quality of life in an asthma clinical trial: What do children's reports tell us?

Robert D. Annett, Bruce G. Bender, Jodi Lapidus, Thomas R. DuHamel, Alan Lincoln

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Objective: To define predictors of disease-specific quality of life (QOL) and the relationship between asthma symptoms and disease-specific QOL. Study design: Three hundred thirty-nine children participated at 4 of 8 Childhood Asthma Management Program clinical centers. Included in the analyses were 2 weeks of asthma symptom data, child-reported health status, and QOL scores from the Pediatric Asthma Quality of Life Questionnaire. Data were obtained 12 months after randomization into the Childhood Asthma Management Program. Results: Children were rated at baseline as having "moderate" asthma (63%) and "mild" asthma (37%). QOL scores were correlated with the child-reported anxiety measures. Factor analysis of the QOL measure resulted in 2 factors. Stepwise multiple regression indicated that the strongest independent predictors of QOL were the child's anxiety level, age, sex, and a measure of the child's tendency to minimize or exaggerate symptoms. Conclusions: Children had few asthma symptoms in the 2 weeks before their 12-month follow-up clinic visit and a generally positive QOL, suggesting that mild-to-moderate asthma does not significantly impair QOL. A child's QOL was predicted primarily by their level of anxiety.

Original languageEnglish (US)
Pages (from-to)854-861
Number of pages8
JournalJournal of Pediatrics
Issue number6
StatePublished - 2001

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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