TY - JOUR
T1 - Predictive value of neutrophil-to-lymphocyte ratio in diabetic wound healing
AU - Vatankhah, Nasibeh
AU - Jahangiri, Younes
AU - Landry, Gregory J.
AU - McLafferty, Robert B.
AU - Alkayed, Nabil J.
AU - Moneta, Gregory L.
AU - Azarbal, Amir F.
N1 - Publisher Copyright:
© 2016 Society for Vascular Surgery
PY - 2017/2/1
Y1 - 2017/2/1
N2 - Objective The neutrophil-to-lymphocyte ratio (NLR) has been used as a surrogate marker of systemic inflammation. We sought to investigate the association between NLR and wound healing in diabetic wounds. Methods The outcomes of 120 diabetic foot ulcers in 101 patients referred from August 2011 to December 2014 were examined retrospectively. Demographic, patient-specific, and wound-specific variables as well as NLR at baseline visit were assessed. Outcomes were classified as ulcer healing, minor amputation, major amputation, and chronic ulcer. Results The subjects’ mean age was 59.4 ± 13.0 years, and 67 (66%) were male. Final outcome was complete healing in 24 ulcers (20%), minor amputation in 58 (48%) and major amputation in 16 (13%), and 22 chronic ulcers (18%) at the last follow-up (median follow-up time, 6.8 months). In multivariate analysis, higher NLR (odds ratio, 13.61; P = .01) was associated with higher odds of nonhealing. Conclusions NLR can predict odds of complete healing in diabetic foot ulcers independent of wound infection and other factors.
AB - Objective The neutrophil-to-lymphocyte ratio (NLR) has been used as a surrogate marker of systemic inflammation. We sought to investigate the association between NLR and wound healing in diabetic wounds. Methods The outcomes of 120 diabetic foot ulcers in 101 patients referred from August 2011 to December 2014 were examined retrospectively. Demographic, patient-specific, and wound-specific variables as well as NLR at baseline visit were assessed. Outcomes were classified as ulcer healing, minor amputation, major amputation, and chronic ulcer. Results The subjects’ mean age was 59.4 ± 13.0 years, and 67 (66%) were male. Final outcome was complete healing in 24 ulcers (20%), minor amputation in 58 (48%) and major amputation in 16 (13%), and 22 chronic ulcers (18%) at the last follow-up (median follow-up time, 6.8 months). In multivariate analysis, higher NLR (odds ratio, 13.61; P = .01) was associated with higher odds of nonhealing. Conclusions NLR can predict odds of complete healing in diabetic foot ulcers independent of wound infection and other factors.
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U2 - 10.1016/j.jvs.2016.08.108
DO - 10.1016/j.jvs.2016.08.108
M3 - Article
C2 - 27887858
AN - SCOPUS:85006970061
SN - 0741-5214
VL - 65
SP - 478
EP - 483
JO - Journal of vascular surgery
JF - Journal of vascular surgery
IS - 2
ER -