Preoperative irradiation for osteogenic sarcoma

Clifford V. Allen; Kenneth R. Stevens

doi:10.1002/1097-0142(197306)31:6<1364::AID-CNCR2820310610>3.0.CO;2-I

Preoperative irradiation for osteogenic sarcoma

Clifford V. Allen, Kenneth R. Stevens

Radiation Medicine

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

High‐dose preoperative irradiation with delayed disarticulation of an extremity involved with osteogenic sarcoma has resulted in a marked increase of tumor‐free survival in a small series of cases treated at the University of Oregon Medical School. Treatment was well tolerated without significant complications. The surgical specimen in most of the survivors contained no viable carcinoma after irradiation in the order of 10,000 rads. There is evidence that biopsy in suspected lesions should be performed without tourniquet to avoid flushing of the tumor cells from the marrow cavity. Discussion will include rationale for delayed surgery, possible influence of irradiation on immune factors, and techniques of irradiation.

Original language	English (US)
Pages (from-to)	1364-1366
Number of pages	3
Journal	Cancer
Volume	31
Issue number	6
DOIs	https://doi.org/10.1002/1097-0142(197306)31:6<1364::AID-CNCR2820310610>3.0.CO;2-I
State	Published - Jun 1973

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1002/1097-0142(197306)31:6<1364::AID-CNCR2820310610>3.0.CO;2-I

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title = "Preoperative irradiation for osteogenic sarcoma",

abstract = "High‐dose preoperative irradiation with delayed disarticulation of an extremity involved with osteogenic sarcoma has resulted in a marked increase of tumor‐free survival in a small series of cases treated at the University of Oregon Medical School. Treatment was well tolerated without significant complications. The surgical specimen in most of the survivors contained no viable carcinoma after irradiation in the order of 10,000 rads. There is evidence that biopsy in suspected lesions should be performed without tourniquet to avoid flushing of the tumor cells from the marrow cavity. Discussion will include rationale for delayed surgery, possible influence of irradiation on immune factors, and techniques of irradiation.",

author = "Allen, {Clifford V.} and Stevens, {Kenneth R.}",

year = "1973",

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AB - High‐dose preoperative irradiation with delayed disarticulation of an extremity involved with osteogenic sarcoma has resulted in a marked increase of tumor‐free survival in a small series of cases treated at the University of Oregon Medical School. Treatment was well tolerated without significant complications. The surgical specimen in most of the survivors contained no viable carcinoma after irradiation in the order of 10,000 rads. There is evidence that biopsy in suspected lesions should be performed without tourniquet to avoid flushing of the tumor cells from the marrow cavity. Discussion will include rationale for delayed surgery, possible influence of irradiation on immune factors, and techniques of irradiation.

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Preoperative irradiation for osteogenic sarcoma

Abstract

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