TY - JOUR
T1 - Presence of circulating immune complexes in Reiter's syndrome and ankylosing spondylitis
AU - Rosenbaum, J. T.
AU - Theofilopoulos, A. N.
AU - McDevitt, H. O.
AU - Pereira, A. B.
AU - Carson, D.
AU - Calin, A.
N1 - Funding Information:
This research was supported in part by grants from the National Institutes of Health (AI 11313, AI 07007, and CA 23322). and Veteran’s Administration Research Funds. Dr. James T. Rosenbaum is supported by a postdoctoral fellowship from The Arthritis Foundation. The Stanford Clinical lm-munology Laboratory and Dolly Ness of the Stanford Blood Bank provided expert technical assistance for portions of this work. A. N. Theofilopoulos is a recipient of Research Career Development Award CA 00303, National Cancer Institute. Dr. Paul Feigenbaum provided constructive comments in preparing this manuscript. A portion of this research was published in abstract form in Clinical Reseurch, February 1980.
PY - 1981/2
Y1 - 1981/2
N2 - Circulating immune complexes (ICs) were sought in the sera of patients with Reiter's syndrome (RS) and ankylosing spondylitis (AS) because (i) the presence of these complexes would support the hypothesis that these diseases are immunologically mediated, and (ii) characterization of the antigen in the complex could provide an important clue toward understanding pathogenesis. Three separate assays were used: the Raji, the conglutinin, and the solid phase anti-C3. All three assays detected complexes in the majority of patients with RS. The Raji was the most sensitive assay, detecting complexes in 67% (20 of 30) patients with RS. Seventy-seven percent of RS patients had detectable complexes by at least one of the three assays. For AS, complexes were present in 69% of the sera studied by the Raji assay. The conglutinin assay gave concordant results. By contrast, the anti-C3 assay did not detect complexes in AS sera. Identification of the antigen in these complexes would elucidate the pathogenesis of these diseases.
AB - Circulating immune complexes (ICs) were sought in the sera of patients with Reiter's syndrome (RS) and ankylosing spondylitis (AS) because (i) the presence of these complexes would support the hypothesis that these diseases are immunologically mediated, and (ii) characterization of the antigen in the complex could provide an important clue toward understanding pathogenesis. Three separate assays were used: the Raji, the conglutinin, and the solid phase anti-C3. All three assays detected complexes in the majority of patients with RS. The Raji was the most sensitive assay, detecting complexes in 67% (20 of 30) patients with RS. Seventy-seven percent of RS patients had detectable complexes by at least one of the three assays. For AS, complexes were present in 69% of the sera studied by the Raji assay. The conglutinin assay gave concordant results. By contrast, the anti-C3 assay did not detect complexes in AS sera. Identification of the antigen in these complexes would elucidate the pathogenesis of these diseases.
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U2 - 10.1016/0090-1229(81)90036-2
DO - 10.1016/0090-1229(81)90036-2
M3 - Article
C2 - 7008993
AN - SCOPUS:0019394955
SN - 0090-1229
VL - 18
SP - 291
EP - 297
JO - Clinical Immunology and Immunopathology
JF - Clinical Immunology and Immunopathology
IS - 2
ER -