Preservation of canine hearts

Donald Trunkey; Thomas Degenhardt; Claude Chartrand; John P. Pryor; Folkert O. Belzer

doi:10.1016/S0011-2240(70)80002-5

Preservation of canine hearts

Donald Trunkey, Thomas Degenhardt, Claude Chartrand, John P. Pryor, Folkert O. Belzer

Trauma, Critical Care and Acute Care Surgery

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Canine hearts were perfused for 24 hrs by hypothermic perfusion. When these hearts were resuscitated they demonstrated pressure-volume curves that were similar to their own control. Electron micrographic studies showed good morphological preservation. However, physiological preservation was not attained, as the orthotopic homotransplanted, preserved heart failed soon after orthotopic implantation.

Original language	English (US)
Pages (from-to)	515-521
Number of pages	7
Journal	Cryobiology
Volume	6
Issue number	6
DOIs	https://doi.org/10.1016/S0011-2240(70)80002-5
State	Published - 1970

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Agricultural and Biological Sciences

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10.1016/S0011-2240(70)80002-5

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@article{733c0e418cca47c98f7f21d2766b9f6c,

title = "Preservation of canine hearts",

abstract = "Canine hearts were perfused for 24 hrs by hypothermic perfusion. When these hearts were resuscitated they demonstrated pressure-volume curves that were similar to their own control. Electron micrographic studies showed good morphological preservation. However, physiological preservation was not attained, as the orthotopic homotransplanted, preserved heart failed soon after orthotopic implantation.",

author = "Donald Trunkey and Thomas Degenhardt and Claude Chartrand and Pryor, {John P.} and Belzer, {Folkert O.}",

note = "Funding Information: Eighty-six mongrel dogs weighing 10 to 15 kg were anesthetized with Diabutol and the heart was exposed through a median ster-notomy. The animals were given heparin and the heart was removM by the technique of Lower, Stofer, and Shumway? The aorta was cannulated with a Teflon cannula, and the Received February 23, t970. * This work was supported by the John A, Hartford Foundation. Inc. Address correspondence to F. O. Belzer.",

year = "1970",

doi = "10.1016/S0011-2240(70)80002-5",

language = "English (US)",

volume = "6",

pages = "515--521",

journal = "Cryobiology",

issn = "0011-2240",

publisher = "Academic Press Inc.",

number = "6",

}

TY - JOUR

T1 - Preservation of canine hearts

AU - Trunkey, Donald

AU - Degenhardt, Thomas

AU - Chartrand, Claude

AU - Pryor, John P.

AU - Belzer, Folkert O.

N1 - Funding Information: Eighty-six mongrel dogs weighing 10 to 15 kg were anesthetized with Diabutol and the heart was exposed through a median ster-notomy. The animals were given heparin and the heart was removM by the technique of Lower, Stofer, and Shumway? The aorta was cannulated with a Teflon cannula, and the Received February 23, t970. * This work was supported by the John A, Hartford Foundation. Inc. Address correspondence to F. O. Belzer.

PY - 1970

Y1 - 1970

N2 - Canine hearts were perfused for 24 hrs by hypothermic perfusion. When these hearts were resuscitated they demonstrated pressure-volume curves that were similar to their own control. Electron micrographic studies showed good morphological preservation. However, physiological preservation was not attained, as the orthotopic homotransplanted, preserved heart failed soon after orthotopic implantation.

AB - Canine hearts were perfused for 24 hrs by hypothermic perfusion. When these hearts were resuscitated they demonstrated pressure-volume curves that were similar to their own control. Electron micrographic studies showed good morphological preservation. However, physiological preservation was not attained, as the orthotopic homotransplanted, preserved heart failed soon after orthotopic implantation.

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U2 - 10.1016/S0011-2240(70)80002-5

DO - 10.1016/S0011-2240(70)80002-5

M3 - Article

C2 - 4914789

AN - SCOPUS:0014789162

SN - 0011-2240

VL - 6

SP - 515

EP - 521

JO - Cryobiology

JF - Cryobiology

IS - 6

ER -

Preservation of canine hearts

Abstract

ASJC Scopus subject areas

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