Production of [11C]CH3I by single pass reaction of [11C]CH4 with I2

Jeanne M. Link, Kenneth A. Krohn, John C. Clark

Research output: Contribution to journalArticlepeer-review

87 Scopus citations


We report a single pass gas phase route to [11C]CHI based on production of I· from I2 at elevated temperature. I· abstracts H from CH4 to yield ·CH3, which reacts with I2 to form CH3I. A fiber optic spectrometer was used to measure the I2 vapor concentration. [11C]CH3I yield increased with I2 concentration until excessive amounts of condensed I2 began to trap the 11C. The yield of [11C]CH3I was >50% from [11C]CH4; its specific activity was 12,000 Ci/mmole. The synthesis takes only 4 min after 11CH4 production and can be repeated without system cleanup.

Original languageEnglish (US)
Pages (from-to)93-97
Number of pages5
JournalNuclear Medicine and Biology
Issue number1
StatePublished - Jan 1997
Externally publishedYes


  • fiber optic spectrometer
  • meta-hydroxyephedrine
  • methyl iodide
  • specific activity measurement for C

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Cancer Research


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