Prognostic factors for survival with gemcitabine plus 5-fluorouracil based regimens for metastatic renal cancer

Walter M. Stadler, Dezheng Huo, Christopher George, Ximing Yang, Christopher W. Ryan, Theodore Karrison, Todd M. Zimmerman, Nicholas J. Vogelzang

Research output: Contribution to journalArticlepeer-review

71 Scopus citations


Purpose: Combination gemcitabine and 5-fluorouracil (5-FU) may have activity in metastatic renal cell cancer. To identify patient subgroups most likely to benefit and compare survival to that in previously described patient series long-term survival as a function of known and suspected prognostic variables was determined. Materials and Methods: The survival status of 153 patients with metastatic renal cell cancer treated on 1 phase I and 4 phase II trials of gemcitabine/5-FU based regimens was updated. Univariate and multivariate Cox proportional hazards models were constructed using multiple imputation for missing values. Results: Performance status, prior nephrectomy, number of metastatic sites, decreased albumin and elevated alkaline phosphatase were highly prognostic for survival. Sarcomatoid differentiation and hypercalcemia had borderline prognostic significance. Using a previous described prognostic model that divided patients into 3 risk groups survival in those treated with gemcitabine/5-FU in this series was consistently better than survival in similar patients treated in the Motzer series. Conclusions: Previously described prognostic factors for survival in metastatic renal cancer were confirmed. There is no clearly identifiable group that is most likely to benefit from a gemcitabine/5-FU regimen but there is a continued suggestion that this regimen provides a modest improvement over historical chemotherapy approaches.

Original languageEnglish (US)
Pages (from-to)1141-1145
Number of pages5
JournalJournal of Urology
Issue number4 I
StatePublished - Oct 1 2003
Externally publishedYes


  • Antineoplastic combined chemotherapy protocols
  • Carcinoma, renal cell
  • Fluorouracil
  • Kidney

ASJC Scopus subject areas

  • Urology


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