Programmable cell adhesion encoded by DNA hybridization

Ravi A. Chandra; Erik S. Douglas; Richard A. Mathies; Carolyn R. Bertozzi; Matthew B. Francis

doi:10.1002/anie.200502421

Programmable cell adhesion encoded by DNA hybridization

Ravi A. Chandra, Erik S. Douglas, Richard A. Mathies, Carolyn R. Bertozzi, Matthew B. Francis

Research output: Contribution to journal › Article › peer-review

154 Scopus citations

Abstract

(Figure Presented) Stuck-on genes: Live cells functionalized with single-stranded DNA oligonucleotides bind, independent of native adhesion mechanisms, to substrates that bear complementary DNA strands in a sequence-specific manner. This strategy has been successfully utilized with several common mammalian cell lines and device platforms.

Original language	English (US)
Pages (from-to)	896-901
Number of pages	6
Journal	Angewandte Chemie - International Edition
Volume	45
Issue number	6
DOIs	https://doi.org/10.1002/anie.200502421
State	Published - Jan 30 2006
Externally published	Yes

Keywords

Cell adhesion
Chemical biology
DNA recognition
Glycoproteins
Staudinger ligation

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.200502421

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title = "Programmable cell adhesion encoded by DNA hybridization",

abstract = "(Figure Presented) Stuck-on genes: Live cells functionalized with single-stranded DNA oligonucleotides bind, independent of native adhesion mechanisms, to substrates that bear complementary DNA strands in a sequence-specific manner. This strategy has been successfully utilized with several common mammalian cell lines and device platforms.",

keywords = "Cell adhesion, Chemical biology, DNA recognition, Glycoproteins, Staudinger ligation",

author = "Chandra, {Ravi A.} and Douglas, {Erik S.} and Mathies, {Richard A.} and Bertozzi, {Carolyn R.} and Francis, {Matthew B.}",

year = "2006",

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AU - Chandra, Ravi A.

AU - Douglas, Erik S.

AU - Mathies, Richard A.

AU - Bertozzi, Carolyn R.

AU - Francis, Matthew B.

PY - 2006/1/30

Y1 - 2006/1/30

N2 - (Figure Presented) Stuck-on genes: Live cells functionalized with single-stranded DNA oligonucleotides bind, independent of native adhesion mechanisms, to substrates that bear complementary DNA strands in a sequence-specific manner. This strategy has been successfully utilized with several common mammalian cell lines and device platforms.

AB - (Figure Presented) Stuck-on genes: Live cells functionalized with single-stranded DNA oligonucleotides bind, independent of native adhesion mechanisms, to substrates that bear complementary DNA strands in a sequence-specific manner. This strategy has been successfully utilized with several common mammalian cell lines and device platforms.

KW - Cell adhesion

KW - Chemical biology

KW - DNA recognition

KW - Glycoproteins

KW - Staudinger ligation

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DO - 10.1002/anie.200502421

M3 - Article

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Programmable cell adhesion encoded by DNA hybridization

Abstract

Keywords

ASJC Scopus subject areas

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