TY - JOUR
T1 - Proinflammatory cytokines and DHEA-S in women with fibromyalgia
T2 - Impact of psychological distress and menopausal status
AU - Sturgeon, John A.
AU - Darnall, Beth D.
AU - Zwickey, Heather L.
AU - Wood, Lisa J.
AU - Hanes, Douglas A.
AU - Zava, David T.
AU - Mackey, Sean C.
N1 - Publisher Copyright:
© 2014 Sturgeon et al.
PY - 2014/12/4
Y1 - 2014/12/4
N2 - Though fibromyalgia is not traditionally considered an inflammatory disorder, evidence for elevated inflammatory processes has been noted in this disorder in multiple studies. Support for inflammatory markers in fibromyalgia has been somewhat equivocal to date, potentially due to inattention to salient patient characteristics that may affect inflammation, such as psychiatric distress and aging milestones like menopause. The current study examined the relationships between proinflammatory cytokines and hormone levels, pain intensity, and psychological distress in a sample of 34 premenopausal and postmenopausal women with fibromyalgia. Our results indicated significant relationships between interleukin-8 and ratings of pain catastrophizing (r=0.555, P,0.05), pain anxiety (r=0.559, P,0.05), and depression (r=0.551, P,0.05) for postmenopausal women but not premenopausal women (r,0.20 in all cases). Consistent with previous studies, ratios of interleukin-6 to interleukin-10 were significantly lower in individuals with greater levels of depressive symptoms (r=−0.239, P,0.05). Contrary to previous research, however, dehydroepiandrosterone sulfate did not correlate with pain intensity or psychological or biological variables. The results of the current study highlight the importance of psychological functioning and milestones of aging in the examination of inflammatory processes in fibromyalgia.
AB - Though fibromyalgia is not traditionally considered an inflammatory disorder, evidence for elevated inflammatory processes has been noted in this disorder in multiple studies. Support for inflammatory markers in fibromyalgia has been somewhat equivocal to date, potentially due to inattention to salient patient characteristics that may affect inflammation, such as psychiatric distress and aging milestones like menopause. The current study examined the relationships between proinflammatory cytokines and hormone levels, pain intensity, and psychological distress in a sample of 34 premenopausal and postmenopausal women with fibromyalgia. Our results indicated significant relationships between interleukin-8 and ratings of pain catastrophizing (r=0.555, P,0.05), pain anxiety (r=0.559, P,0.05), and depression (r=0.551, P,0.05) for postmenopausal women but not premenopausal women (r,0.20 in all cases). Consistent with previous studies, ratios of interleukin-6 to interleukin-10 were significantly lower in individuals with greater levels of depressive symptoms (r=−0.239, P,0.05). Contrary to previous research, however, dehydroepiandrosterone sulfate did not correlate with pain intensity or psychological or biological variables. The results of the current study highlight the importance of psychological functioning and milestones of aging in the examination of inflammatory processes in fibromyalgia.
KW - Cytokines
KW - Fibromyalgia
KW - Inflammation
KW - Psychological distress
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U2 - 10.2147/JPR.S71344
DO - 10.2147/JPR.S71344
M3 - Article
AN - SCOPUS:84916934387
SN - 1178-7090
VL - 7
SP - 707
EP - 716
JO - Journal of Pain Research
JF - Journal of Pain Research
ER -