Promoting Lymphangiogenesis and Lymphatic Growth and Remodeling to Treat Cardiovascular and Metabolic Diseases

Xiaolei Liu, Kui Cui, Hao Wu, Kathryn S. Li, Qianman Peng, Donghai Wang, Douglas B. Cowan, J. Brandon Dixon, R. Sathish Srinivasan, Diane R. Bielenberg, Kaifu Chen, Da Zhi Wang, Yabing Chen, Hong Chen

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations

Abstract

Lymphatic vessels are low-pressure, blind-ended tubular structures that play a crucial role in the maintenance of tissue fluid homeostasis, immune cell trafficking, and dietary lipid uptake and transport. Emerging research has indicated that the promotion of lymphatic vascular growth, remodeling, and function can reduce inflammation and diminish disease severity in several pathophysiologic conditions. In particular, recent groundbreaking studies have shown that lymphangiogenesis, which describes the formation of new lymphatic vessels from the existing lymphatic vasculature, can be beneficial for the alleviation and resolution of metabolic and cardiovascular diseases. Therefore, promoting lymphangiogenesis represents a promising therapeutic approach. This brief review summarizes the most recent findings related to the modulation of lymphatic function to treat metabolic and cardiovascular diseases such as obesity, myocardial infarction, atherosclerosis, and hypertension. We also discuss experimental and therapeutic approaches to enforce lymphatic growth and remodeling as well as efforts to define the molecular and cellular mechanisms underlying these processes.

Original languageEnglish (US)
Pages (from-to)E1-E10
JournalArteriosclerosis, thrombosis, and vascular biology
Volume43
Issue number1
DOIs
StatePublished - Jan 1 2023
Externally publishedYes

Keywords

  • atherosclerosis
  • cardiovascular disease
  • diabetes
  • hypertension
  • myocardial infarction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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