@article{996d6e80a6164f7fbc13dcabb8151b68,
title = "Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer",
abstract = "The murine Pten prostate cancer model described in this study recapitulates the disease progression seen in humans: initiation of prostate cancer with prostatic intraepithelial neoplasia (PIN), followed by progression to invasive adenocarcinoma, and subsequent metastasis with defined kinetics. Furthermore, while Pten null prostate cancers regress after androgen ablation, they are capable of proliferating in the absence of androgen. Global assessment of molecular changes caused by homozygous Pten deletion identified key genes known to be relevant to human prostate cancer, including those {"}signature{"} genes associated with human cancer metastasis. This murine prostate cancer model provides a unique tool for both exploring the molecular mechanism underlying prostate cancer and for development of new targeted therapies.",
author = "Shunyou Wang and Jing Gao and Qunying Lei and Nora Rozengurt and Colin Pritchard and Jing Jiao and Thomas, {George V.} and Gang Li and Pradip Roy-Burman and Nelson, {Peter S.} and Xin Liu and Hong Wu",
note = "Funding Information: We thank Drs. Sawyers, Chow, Wu, Herschman, and Reiter and members of our laboratories for helpful comments; Drs. Ellwood and Sawyers for exchanging unpublished results; Dr. Robert Cardiff and Robert J. Munn for pathology analysis; Dr. Abate-Shen for anti-Nkx3.1 antibody; Drs. Reiter and Witte for anti-PSCA antibody; Dr. Lily Wu for AR immunohistochemistry; and Ms. Lawson for technical assistance. H.W. is an Assistant Investigator of the Howard Hughes Medical Institute (HHMI). S.W and G.L. are supported by the grant from DOD: PC991538 and NIH CA98013. G.V.T. is supported by a grant from DOD: PC010383 and UCLA Prostate SPORE career Development grant. P.S.N. is supported in part by a Damon Runion scholar award. This work was partially supported by grants from NIH: CA98013, DOD: PC991538, and CapCure (to H.W.), and NIH CA 59705 (to P.R.-B.), and NIH DK65204 and DK59125 (to P.S.N.). ",
year = "2003",
month = sep,
day = "1",
doi = "10.1016/S1535-6108(03)00215-0",
language = "English (US)",
volume = "4",
pages = "209--221",
journal = "Cancer Cell",
issn = "1535-6108",
publisher = "Cell Press",
number = "3",
}