@article{13f6383aa8bb44ba91d115ebd9eedd4a,
title = "Prostratin exhibits both replication enhancing and inhibiting effects on FIV infection of feline CD4+ T-cells",
abstract = "The phorbol ester Prostratin may either stimulate or inhibit human immunodeficiency virus-1 (HIV-1) replication. Here we report that Prostratin also exhibits a similar dual action upon feline immunodeficiency virus (FIV) replication in an IL-2-dependent feline CD4+ T-cell line (MYA-1). While withdrawal of IL-2 halted FIV spread, Prostratin rescued virus production and cell viability, mimicking the functions of the cytokine. Conversely, FIV grew rapidly in the presence of IL-2 and this was inhibited by Prostratin. In contrast to HIV-1, Prostratin mediated inhibition of FIV through means other than blocking virus entry. Co-application of the protein kinase C (PKC) inhibitor G{\"o}6850 with Prostratin reversed both the inhibitory and stimulatory effects, suggesting that PKC is crucial for FIV replication.",
keywords = "CD4 T-cells, FIV, HIV-1, IL-2, PKC, PMA, Prostratin, Protein kinase C",
author = "Chan, \{Chi Ngai\} and McMonagle, \{Elizabeth L.\} and Hosie, \{Margaret J.\} and Willett, \{Brian J.\}",
year = "2013",
month = jan,
doi = "10.1016/j.virusres.2012.11.004",
language = "English (US)",
volume = "171",
pages = "121--128",
journal = "Virus Research",
issn = "0168-1702",
publisher = "Elsevier B.V.",
number = "1",
}