TY - JOUR
T1 - Protection against experimental encephalomyelitis
T2 - Idiotypic autoregulation induced by a nonencephalitogenic T cell clone expressing a cross-reactive T cell receptor V gene
AU - Offner, Halina
AU - Vainiene, Margarita
AU - Gold, Daniel P.
AU - Morrison, William J.
AU - Wang, Run Ying
AU - Hashim, George A.
AU - Vandenbark, Arthur A.
PY - 1991/6/15
Y1 - 1991/6/15
N2 - The recovery process in experimental autoimmune encephalomyelitis (EAE) in Lewis rats is characterized by an increasing diversity of T cell clones directed at secondary epitopes of myelin basic protein. Of particular interest, residues 55 to 69 of guinea pig basic protein could induce protection against EAE. A nonencephalitogenic T cell clone, C455-69, that was specific for this epitope transferred protection against both active and passive EAE. Clone C455-69 was found to express Vβ8.6 in its Ag receptor, and residues 39 to 59 of the TCR Vβ8.6 sequence were found to be highly crossreactive with the corresponding residues 39 to 59 of TCR Vβ8.2, which is known to induce protective anti-idiotypic T cells and antibodies. Like the TCR Vβ8.239-59 peptide, the Vβ8.639-59 sequence induced autoregulation and provided effective treatment of established EAE. Thus, the EAE-protective effect of the guinea pig basic protein 55-69 sequence was most likely mediated by T cell clones such as C455-69 that could efficiently induce anti-TCR immunity directed at a cross-reactive regulatory idiotope.
AB - The recovery process in experimental autoimmune encephalomyelitis (EAE) in Lewis rats is characterized by an increasing diversity of T cell clones directed at secondary epitopes of myelin basic protein. Of particular interest, residues 55 to 69 of guinea pig basic protein could induce protection against EAE. A nonencephalitogenic T cell clone, C455-69, that was specific for this epitope transferred protection against both active and passive EAE. Clone C455-69 was found to express Vβ8.6 in its Ag receptor, and residues 39 to 59 of the TCR Vβ8.6 sequence were found to be highly crossreactive with the corresponding residues 39 to 59 of TCR Vβ8.2, which is known to induce protective anti-idiotypic T cells and antibodies. Like the TCR Vβ8.239-59 peptide, the Vβ8.639-59 sequence induced autoregulation and provided effective treatment of established EAE. Thus, the EAE-protective effect of the guinea pig basic protein 55-69 sequence was most likely mediated by T cell clones such as C455-69 that could efficiently induce anti-TCR immunity directed at a cross-reactive regulatory idiotope.
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M3 - Article
C2 - 1710243
AN - SCOPUS:0025955351
SN - 0022-1767
VL - 146
SP - 4165
EP - 4172
JO - Journal of Immunology
JF - Journal of Immunology
IS - 12
ER -