@article{c42baf1a3d8a48f5947216f7718a1b87,
title = "Proteogenomic Characterization of Endometrial Carcinoma",
abstract = "We undertook a comprehensive proteogenomic characterization of 95 prospectively collected endometrial carcinomas, comprising 83 endometrioid and 12 serous tumors. This analysis revealed possible new consequences of perturbations to the p53 and Wnt/β-catenin pathways, identified a potential role for circRNAs in the epithelial-mesenchymal transition, and provided new information about proteomic markers of clinical and genomic tumor subgroups, including relationships to known druggable pathways. An extensive genome-wide acetylation survey yielded insights into regulatory mechanisms linking Wnt signaling and histone acetylation. We also characterized aspects of the tumor immune landscape, including immunogenic alterations, neoantigens, common cancer/testis antigens, and the immune microenvironment, all of which can inform immunotherapy decisions. Collectively, our multi-omic analyses provide a valuable resource for researchers and clinicians, identify new molecular associations of potential mechanistic significance in the development of endometrial cancers, and suggest novel approaches for identifying potential therapeutic targets.",
keywords = "CTNNB1, TP53, acetylation, circular RNA, endometrial cancer, endometrioid endometrial cancer, immune evasion, proteogenomics, proteomics, serous endometrial cancer",
author = "{the Clinical Proteomic Tumor Analysis Consortium} and Yongchao Dou and Kawaler, {Emily A.} and {Cui Zhou}, Daniel and Gritsenko, {Marina A.} and Chen Huang and Lili Blumenberg and Alla Karpova and Petyuk, {Vladislav A.} and Savage, {Sara R.} and Shankha Satpathy and Wenke Liu and Yige Wu and Tsai, {Chia Feng} and Bo Wen and Zhi Li and Song Cao and Jamie Moon and Zhiao Shi and MacIntosh Cornwell and Wyczalkowski, {Matthew A.} and Chu, {Rosalie K.} and Suhas Vasaikar and Hua Zhou and Qingsong Gao and Moore, {Ronald J.} and Kai Li and Sunantha Sethuraman and Monroe, {Matthew E.} and Rui Zhao and David Heiman and Karsten Krug and Karl Clauser and Ramani Kothadia and Yosef Maruvka and Pico, {Alexander R.} and Oliphant, {Amanda E.} and Hoskins, {Emily L.} and Pugh, {Samuel L.} and Beecroft, {Sean J.I.} and Adams, {David W.} and Jarman, {Jonathan C.} and Andy Kong and Chang, {Hui Yin} and Anupriya Agarwal and Uma Borate and Emek Demir and Brian Druker and Cristina Tognon and Elie Traer and Jeffrey Tyner",
note = "Funding Information: This work was supported by the National Cancer Institute (NCI) Clinical Proteomic Tumor Analysis Consortium (CPTAC) grants U24CA210955 , U24CA210954 , U24CA210972 , U24CA210979 , U24CA210986 , and U01CA214125 ; by grant RR160027 from the Cancer Prevention & Research Institutes of Texas (CPRIT); and by funding from the McNair Medical Institute at The Robert and Janice McNair Foundation . B.Z. and M.E. are Cancer Prevention & Research Institutes of Texas Scholars in Cancer Research and McNair Medical Institute Scholars. The Pacific Northwest National Laboratory (PNNL) proteomics work described herein was performed in the Environmental Molecular Sciences Laboratory, a US Department of Energy (DOE) National Scientific User Facility located at PNNL in Richland, WA. PNNL is a multi-program national laboratory operated by the Battelle Memorial Institute for the DOE under contract DE-AC05-76RL01830 . Funding Information: This work was supported by the National Cancer Institute (NCI) Clinical Proteomic Tumor Analysis Consortium (CPTAC) grants U24CA210955, U24CA210954, U24CA210972, U24CA210979, U24CA210986, and U01CA214125; by grant RR160027 from the Cancer Prevention & Research Institutes of Texas (CPRIT); and by funding from the McNair Medical Institute at The Robert and Janice McNair Foundation. B.Z. and M.E. are Cancer Prevention & Research Institutes of Texas Scholars in Cancer Research and McNair Medical Institute Scholars. The Pacific Northwest National Laboratory (PNNL) proteomics work described herein was performed in the Environmental Molecular Sciences Laboratory, a US Department of Energy (DOE) National Scientific User Facility located at PNNL in Richland, WA. PNNL is a multi-program national laboratory operated by the Battelle Memorial Institute for the DOE under contract DE-AC05-76RL01830. Study Conception and Design: Y.D. E.A.K. D.C.Z. K.D.R. L.D. B.Z. T.L. and D.F.; Performed Experiment or Data Collection: M.A.G. C.T. J.M. R.K.C. R.J.M. M.E.M. R.Z. A. Czeka?ski, M.J. R.M. and M.W.; Computation and Statistical Analysis: Y.D. E.A.K. D.C.Z. C.H. L.B. A. Karpova, V.A.P. S.R.S. S. Satpathy, W.L. Y.W. B.W. Z.L. S.C. Z.S. M.C. M.A.W. S.V. H.Z. Q.G. K.L. S. Sethuraman, D.H. K.K. K.C. R.K. Y.M. A.P. A.E.O. E.L.H. S.L.P. S.J.I.B. D.W.A. J.C.J. A. Kong, H.C. B.R. Y.L. D.R. A. Colaprico, X.S.C. D.D. M.T. S.H.P. and K.V.R.; Data Interpretation and Biological Analysis: Y.D. E.A.K. D.C.Z. C.H. L.B. A. Karpova, S.R.S. S. Satpathy, W.L. Y.W. K.D.R. L.D. B.Z. T.L. and D.F.; Writing ? Original Drafts: Y.D. E.A.K. D.C.Z. M.A.G. C.H. L.B. A. Karpova, V.A.P. S.R.S. M.E. D.D. M.L.A. D.A.L. S.H.P. K.V.R. K.D.R. L.D. B.Z. T.L. and D.F.; Writing ? Review and Editing: All; Supervision: D.R.M. G.G. M.N. A.I.N. P.W. R.D.S. S.H.P. K.V.R. L.D. B.Z. T.L. and D.F.; Administration: L.D. B.Z. T.L. and D.F. The authors declare no competing interests. Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2020",
month = feb,
day = "20",
doi = "10.1016/j.cell.2020.01.026",
language = "English (US)",
volume = "180",
pages = "729--748.e26",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "4",
}