Pulicatins A-E, neuroactive thiazoline metabolites from cone snail-associated bacteria

Zhenjian Lin, Rowena R. Antemano, Ronald W. Hughen, Ma Diarey B. Tianero, Olivier Peraud, Margo G. Haygood, Gisela P. Concepcion, Baldomero M. Olivera, Alan Light, Eric W. Schmidt

Research output: Contribution to journalArticlepeer-review

51 Scopus citations


The cone snail Conus pulicarius from the Philippines provides a specific habitat for actinomycetes and other bacteria. A phenotypic screen using primary cultures of mouse dorsal root ganglion neurons revealed that one C. pulicarius associate, Streptomyces sp. CP32, produces a series of natural products that enhance or diminish whole-cell Ca2+ flux. These compounds include known thiazoline compounds and a series of new derivatives, pulicatins A-E (6-10). Individual compounds were shown to bind to a series of human receptors, with selective binding to the human serotonin 5-HT2B receptor. Here, we report the structure elucidation of the new compounds and results of the neurological assays.

Original languageEnglish (US)
Pages (from-to)1922-1926
Number of pages5
JournalJournal of Natural Products
Issue number11
StatePublished - Nov 29 2010
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry


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