Pulmonary Manifestations of Primary Immunodeficiency Disorders

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations


Pulmonary disease, ranging from infectious pneumonia, lung abscess, and empyema to structural lung diseases to malignancy, significantly increase morbidity and mortality in primary immune deficiency. Treatment with supplemental immunoglobulin (intravenous or subcutaneous) and antimicrobials is beneficial in reducing infections but are largely ineffective in preventing noninfectious complications, including interstitial lung disease, malignancy, and autoimmune disease. A low threshold for suspecting pulmonary complications is necessary for the early diagnosis of pulmonary involvement in primary immunodeficiency disorders, before irreversible damage is done, to improve patient outcomes.

Original languageEnglish (US)
Pages (from-to)753-766
Number of pages14
JournalImmunology and Allergy Clinics of North America
Issue number4
StatePublished - Nov 2015


  • Bronchiectasis
  • Common variable immune deficiency
  • Interstitial lung disease
  • Primary immunodeficiency disease
  • Pulmonary complication

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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