Pulmonary nontuberculous mycobacteria-associated deaths, Ontario, Canada, 2001-2013

Theodore K. Marras, Michael A. Campitelli, Hong Lu, Hannah Chung, Sarah K. Brode, Alex Marchand-Austin, Kevin L. Winthrop, Andrea S. Gershon, Jeffrey C. Kwong, Frances B. Jamieson

Research output: Contribution to journalArticlepeer-review

57 Scopus citations


Survival implications of nontuberculous mycobacterial pulmonary disease (NTM-PD) and NTM pulmonary isolation without disease (NTM-PI) are unclear. To study deaths associated with NTM-PD and NTM-PI and differences in survival between them, we conducted a population-based cohort study of persons with microbiologically defined NTM-PD or NTM-PI diagnosed during 2001-2013 in Ontario, Canada. We used propensity score matching and Cox proportional hazards models to compare survival. Among 9,681 NTMPD patients and 10,936 NTM-PI patients, 87% and 91%, respectively, were successfully matched with unexposed controls. Both NTM-PD and NTM-PI were associated with higher rates of death for all species combined and for most individual species. Compared with NTM-PI, NTM-PD was associated with higher death rates for all species combined, Mycobacterium avium complex, and M. xenopi. NTM-PD and NTM-PI were significantly associated with death, NTMPD more so than NTM-PI.

Original languageEnglish (US)
Pages (from-to)468-476
Number of pages9
JournalEmerging infectious diseases
Issue number3
StatePublished - Mar 2017

ASJC Scopus subject areas

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases


Dive into the research topics of 'Pulmonary nontuberculous mycobacteria-associated deaths, Ontario, Canada, 2001-2013'. Together they form a unique fingerprint.

Cite this