TY - JOUR
T1 - Pyoderma gangrenosum
T2 - a review with special emphasis on Latin America literature
AU - Rodríguez-Zúñiga, Milton José Max
AU - Heath, Michael S.
AU - Gontijo, João Renato Vianna
AU - Ortega-Loayza, Alex G.
N1 - Publisher Copyright:
© 2019 Sociedade Brasileira de Dermatologia
PY - 2019/11/1
Y1 - 2019/11/1
N2 - Pyoderma gangrenosum is a neutrophilic dermatosis characterized by chronic ulcers due to an abnormal immune response. Despite the existence of diagnostic criteria, there is no gold standard for diagnosis or treatment. In Latin America, recognizing and treating pyoderma gangrenosum is even more challenging since skin and soft tissue bacterial and non-bacterial infections are common mimickers. Therefore, this review aims to characterize reported cases of pyoderma gangrenosum in this region in order to assist in the assessment and management of this condition. Brazil, Mexico, Argentina, and Chile are the countries in Latin America that have reported the largest cohort of patients with this disease. The most frequent clinical presentation is the ulcerative form and the most frequently associated conditions are inflammatory bowel diseases, inflammatory arthropaties, and hematologic malignancies. The most common treatment modalities include systemic corticosteroids and cyclosporine. Other reported treatments are methotrexate, dapsone, and cyclophosphamide. Finally, the use of biological therapy is still limited in this region.
AB - Pyoderma gangrenosum is a neutrophilic dermatosis characterized by chronic ulcers due to an abnormal immune response. Despite the existence of diagnostic criteria, there is no gold standard for diagnosis or treatment. In Latin America, recognizing and treating pyoderma gangrenosum is even more challenging since skin and soft tissue bacterial and non-bacterial infections are common mimickers. Therefore, this review aims to characterize reported cases of pyoderma gangrenosum in this region in order to assist in the assessment and management of this condition. Brazil, Mexico, Argentina, and Chile are the countries in Latin America that have reported the largest cohort of patients with this disease. The most frequent clinical presentation is the ulcerative form and the most frequently associated conditions are inflammatory bowel diseases, inflammatory arthropaties, and hematologic malignancies. The most common treatment modalities include systemic corticosteroids and cyclosporine. Other reported treatments are methotrexate, dapsone, and cyclophosphamide. Finally, the use of biological therapy is still limited in this region.
KW - Inflammatory bowel diseases
KW - Latin America
KW - Pyoderma gangrenosum
KW - Skin ulcer
UR - http://www.scopus.com/inward/record.url?scp=85076774819&partnerID=8YFLogxK
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U2 - 10.1016/j.abd.2019.06.001
DO - 10.1016/j.abd.2019.06.001
M3 - Review article
C2 - 31789268
AN - SCOPUS:85076774819
SN - 0365-0596
VL - 94
SP - 729
EP - 743
JO - Anais brasileiros de dermatologia
JF - Anais brasileiros de dermatologia
IS - 6
ER -