Pyoderma Gangrenosum: What Do We Know Now?

Fatima McKenzie, Megan Arthur, Alex G. Ortega-Loayza

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations


Purpose of Review: To summarize the recent literature on the pathophysiology, diagnosis, and treatment of pyoderma gangrenosum. Recent Findings: A complex interplay between both the innate and adaptive immune systems underlies the pathogenesis of pyoderma gangrenosum (PG). Diagnosis remains a challenge, as there is no gold standard test to confirm the presence of the disease. Efforts to establish diagnostic criteria based on clinical findings have recently been proposed. Definitive management strategies are also lacking; however, current trends in treatment have favored the use of immunosuppressive medications, wound care management, and analgesia. Summary: PG is a complex disease that continues to pose a challenge. Current research on PG is focused on improving our understanding of the pathophysiology so that we might improve our diagnostic consistency and identify treatment approaches optimized for each individual patient’s specific pathology.

Original languageEnglish (US)
Pages (from-to)147-157
Number of pages11
JournalCurrent Dermatology Reports
Issue number3
StatePublished - Sep 1 2018


  • Neutrophilic dermatosis
  • Pyoderma gangrenosum
  • Wounds

ASJC Scopus subject areas

  • Dermatology


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