Pyrazole exacerbates handling-induced convulsions in mice

J. C. Crabbe; E. R. Young; J. Janowsky; H. Rigter

doi:10.1016/0028-3908(81)90215-X

Pyrazole exacerbates handling-induced convulsions in mice

J. C. Crabbe, E. R. Young, J. Janowsky, H. Rigter

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Severity of handling-induced convulsions was reduced in mice in comparison to the scores on an initial test administered 4 days earlier. Daily injections of pyrazole, an inhibitor of alcohol dehydrogenase, prevented the reduction of convulsions in handled mice and exacerbated convulsions in mice tested for the first time after injection. The effects of pyrazole were dose-related.

Original language	English (US)
Pages (from-to)	605-609
Number of pages	5
Journal	Neuropharmacology
Volume	20
Issue number	6
DOIs	https://doi.org/10.1016/0028-3908(81)90215-X
State	Published - Jun 1981
Externally published	Yes

Keywords

convulsions
handling induced
mice
pyrazole
refractory period

ASJC Scopus subject areas

Pharmacology
Cellular and Molecular Neuroscience

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10.1016/0028-3908(81)90215-X

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title = "Pyrazole exacerbates handling-induced convulsions in mice",

abstract = "Severity of handling-induced convulsions was reduced in mice in comparison to the scores on an initial test administered 4 days earlier. Daily injections of pyrazole, an inhibitor of alcohol dehydrogenase, prevented the reduction of convulsions in handled mice and exacerbated convulsions in mice tested for the first time after injection. The effects of pyrazole were dose-related.",

keywords = "convulsions, handling induced, mice, pyrazole, refractory period",

author = "Crabbe, {J. C.} and Young, {E. R.} and J. Janowsky and H. Rigter",

note = "Funding Information: Acknowledgements-Thisw ork was supported by the Medical ResearchS erviceo f the VeteransA dministration. We thank Dan Gray and An Irwin for assistance, and Dr D. B. Goldstein for her comments on a draft of this manuscript.",

year = "1981",

month = jun,

doi = "10.1016/0028-3908(81)90215-X",

language = "English (US)",

volume = "20",

pages = "605--609",

journal = "Neuropharmacology",

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T1 - Pyrazole exacerbates handling-induced convulsions in mice

AU - Crabbe, J. C.

AU - Young, E. R.

AU - Janowsky, J.

AU - Rigter, H.

N1 - Funding Information: Acknowledgements-Thisw ork was supported by the Medical ResearchS erviceo f the VeteransA dministration. We thank Dan Gray and An Irwin for assistance, and Dr D. B. Goldstein for her comments on a draft of this manuscript.

PY - 1981/6

Y1 - 1981/6

N2 - Severity of handling-induced convulsions was reduced in mice in comparison to the scores on an initial test administered 4 days earlier. Daily injections of pyrazole, an inhibitor of alcohol dehydrogenase, prevented the reduction of convulsions in handled mice and exacerbated convulsions in mice tested for the first time after injection. The effects of pyrazole were dose-related.

AB - Severity of handling-induced convulsions was reduced in mice in comparison to the scores on an initial test administered 4 days earlier. Daily injections of pyrazole, an inhibitor of alcohol dehydrogenase, prevented the reduction of convulsions in handled mice and exacerbated convulsions in mice tested for the first time after injection. The effects of pyrazole were dose-related.

KW - convulsions

KW - handling induced

KW - mice

KW - pyrazole

KW - refractory period

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JO - Neuropharmacology

JF - Neuropharmacology

IS - 6

ER -

Pyrazole exacerbates handling-induced convulsions in mice

Abstract

Keywords

ASJC Scopus subject areas

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