Quantifying blood flow and wall shear stresses in the outflow tract of chick embryonic hearts

Aiping Liu; Andrew Nickerson; Aaron Troyer; Xin Yin; Robert Cary; Kent Thornburg; Ruikang Wang; Sandra Rugonyi

doi:10.1016/j.compstruc.2011.03.003

Quantifying blood flow and wall shear stresses in the outflow tract of chick embryonic hearts

Aiping Liu, Andrew Nickerson, Aaron Troyer, Xin Yin, Robert Cary, Kent Thornburg, Ruikang Wang, Sandra Rugonyi

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

Wall shear stresses (WSS) exerted by blood flow on cardiac tissues modulate growth and development of the heart. To study the role of hemodynamic conditions on cardiac morphogenesis, here, we present a methodology that combines imaging and finite element modeling to quantitate the in vivo blood flow dynamics and WSS in the cardiac outflow tract (OFT) of early chicken embryos (day 3 out of 21-day incubation). We found a distinct blood flow field and heterogeneous distribution of WSS in the chicken embryonic heart OFT, which have physiological implications for OFT morphogenesis.

Original language	English (US)
Pages (from-to)	855-867
Number of pages	13
Journal	Computers and Structures
Volume	89
Issue number	11-12
DOIs	https://doi.org/10.1016/j.compstruc.2011.03.003
State	Published - Jun 2011

Keywords

Cardiac outflow tract
Chick embryonic heart
Computational fluid dynamics
Wall shear stress

ASJC Scopus subject areas

Civil and Structural Engineering
Modeling and Simulation
Materials Science(all)
Mechanical Engineering
Computer Science Applications

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10.1016/j.compstruc.2011.03.003

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title = "Quantifying blood flow and wall shear stresses in the outflow tract of chick embryonic hearts",

abstract = "Wall shear stresses (WSS) exerted by blood flow on cardiac tissues modulate growth and development of the heart. To study the role of hemodynamic conditions on cardiac morphogenesis, here, we present a methodology that combines imaging and finite element modeling to quantitate the in vivo blood flow dynamics and WSS in the cardiac outflow tract (OFT) of early chicken embryos (day 3 out of 21-day incubation). We found a distinct blood flow field and heterogeneous distribution of WSS in the chicken embryonic heart OFT, which have physiological implications for OFT morphogenesis.",

keywords = "Cardiac outflow tract, Chick embryonic heart, Computational fluid dynamics, Wall shear stress",

author = "Aiping Liu and Andrew Nickerson and Aaron Troyer and Xin Yin and Robert Cary and Kent Thornburg and Ruikang Wang and Sandra Rugonyi",

note = "Funding Information: This work was funded by NIH R01HL094570 (S. Rugonyi, PI) and AHA pre-doctoral fellowship 0910093G (A. Liu, PI). The authors would like to thank Dr. Sandra Oster for her editorial help and thank Dr. Ian Sigal for inspiring discussions. We would also like to thank Dr. Zhenhe Ma for customizing the OCT system for imaging chick embryonic hearts and Dr. Yuming Liu for aid in figure preparation.",

year = "2011",

month = jun,

doi = "10.1016/j.compstruc.2011.03.003",

language = "English (US)",

volume = "89",

pages = "855--867",

journal = "Computers and Structures",

issn = "0045-7949",

publisher = "Elsevier Limited",

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TY - JOUR

T1 - Quantifying blood flow and wall shear stresses in the outflow tract of chick embryonic hearts

AU - Liu, Aiping

AU - Nickerson, Andrew

AU - Troyer, Aaron

AU - Yin, Xin

AU - Cary, Robert

AU - Thornburg, Kent

AU - Wang, Ruikang

AU - Rugonyi, Sandra

N1 - Funding Information: This work was funded by NIH R01HL094570 (S. Rugonyi, PI) and AHA pre-doctoral fellowship 0910093G (A. Liu, PI). The authors would like to thank Dr. Sandra Oster for her editorial help and thank Dr. Ian Sigal for inspiring discussions. We would also like to thank Dr. Zhenhe Ma for customizing the OCT system for imaging chick embryonic hearts and Dr. Yuming Liu for aid in figure preparation.

PY - 2011/6

Y1 - 2011/6

N2 - Wall shear stresses (WSS) exerted by blood flow on cardiac tissues modulate growth and development of the heart. To study the role of hemodynamic conditions on cardiac morphogenesis, here, we present a methodology that combines imaging and finite element modeling to quantitate the in vivo blood flow dynamics and WSS in the cardiac outflow tract (OFT) of early chicken embryos (day 3 out of 21-day incubation). We found a distinct blood flow field and heterogeneous distribution of WSS in the chicken embryonic heart OFT, which have physiological implications for OFT morphogenesis.

AB - Wall shear stresses (WSS) exerted by blood flow on cardiac tissues modulate growth and development of the heart. To study the role of hemodynamic conditions on cardiac morphogenesis, here, we present a methodology that combines imaging and finite element modeling to quantitate the in vivo blood flow dynamics and WSS in the cardiac outflow tract (OFT) of early chicken embryos (day 3 out of 21-day incubation). We found a distinct blood flow field and heterogeneous distribution of WSS in the chicken embryonic heart OFT, which have physiological implications for OFT morphogenesis.

KW - Cardiac outflow tract

KW - Chick embryonic heart

KW - Computational fluid dynamics

KW - Wall shear stress

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DO - 10.1016/j.compstruc.2011.03.003

M3 - Article

AN - SCOPUS:79955573444

SN - 0045-7949

VL - 89

SP - 855

EP - 867

JO - Computers and Structures

JF - Computers and Structures

IS - 11-12

ER -

Quantifying blood flow and wall shear stresses in the outflow tract of chick embryonic hearts

Abstract

Keywords

ASJC Scopus subject areas

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