Abstract
The rat corticosterone secretion rate determined fluorimetrically from 3-minute samples of adrenal effluent (123 ± 5.3 μg/kg/adrenal/hr) agrees well with values reported for more extended collection periods and analyzed by other methods. Dexamethasone-21-phosphate, a non-fluorescing, corticotropin-suppressing, synthetic steroid was found to produce maximal suppression of the corticosterone secretion rate 4 to 8 hours following a single dose. The technic described may be applied to assays of corticotropin itself or assays of corticotropin suppressing activity of other non-fluorescing agents.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 926-928 |
| Number of pages | 3 |
| Journal | Proceedings of the Society for Experimental Biology and Medicine |
| Volume | 107 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1961 |
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology