Quantitative Drug Target Imaging Using Paired-Agent Principles

Kenneth M. Tichauer, Negar Sadeghipour, Yu Winston Wang, Summer L. Gibbs, Jonathan T.C. Liu, Kimberley S. Samkoe

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations


Molecular imaging is often proposed to provide a direct measure of drug targets; however, physiological effects of imaging-agent delivery rates and nonspecific retention can obfuscate the relationship between imaging-agent distribution and the biological distribution of the targeted biomolecule. Coadministration of a suitable control imaging-agent (“nontargeted” version of the targeted agent) simultaneously with a targeted imaging-agent offers a promising solution to account for the nonspecific effects in single-agent molecular imaging and can provide quantitative measures of drug target distribution and availability. This chapter provides an overview of these “paired-agent” molecular imaging protocols with thorough descriptions of how to extract estimates of drug target concentration from paired-agent data under a number of conditions: topical and systemic delivery, and imaging of intravascular, extracellular, and intracellular drug targets.

Original languageEnglish (US)
Title of host publicationMethods in Pharmacology and Toxicology
PublisherHumana Press Inc.
Number of pages30
StatePublished - 2021

Publication series

NameMethods in Pharmacology and Toxicology
ISSN (Print)1557-2153
ISSN (Electronic)1940-6053


  • Cancer
  • Drug target
  • Kinetic modeling
  • Molecular imaging
  • Paired-agent

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)


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