Abstract
Alkyl dimethyl benzyl ammonium chloride (ADBAC) and didecyl dimethyl ammonium chloride (DDAC) are common ingredients in household bathroom and kitchen cleaning sprays. ADBAC + DDAC cause reproductive toxicity in mice. The aim of the present study was to investigate gender-specific reproductive effects from ADBAC + DDAC. Female reproduction was assessed through ovulation, oocyte implantation, and estrus cycling. Male reproductive function was assessed by sperm concentration, motility, and viability. Numbers of corpora lutea were not different after 2 weeks, but decreased after 8 weeks of ADBAC + DDAC exposure. Dams exposed for 5 weeks to ADBAC + DDAC spent significantly less time in estrus. ADBAC + DDAC exposed males exhibited declines in both sperm concentration and motility, but not sperm viability. Subfertility in mice from ADBAC + DDAC exposure is, therefore, mediated through reproductive disturbances in both females and males. While the effect of ADBAC + DDAC exposure on human health is unclear, widespread exposure necessitates further consideration of their potential reproductive toxicity.
Original language | English (US) |
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Pages (from-to) | 159-166 |
Number of pages | 8 |
Journal | Reproductive Toxicology |
Volume | 59 |
DOIs | |
State | Published - Jan 1 2016 |
Externally published | Yes |
Keywords
- Disinfectants
- Fertility
- Implantation
- Ovulation
- Quaternary ammonium compounds
- Reproduction
- Sperm counts
ASJC Scopus subject areas
- Toxicology