Radionuclide Detection of Diffuse Interstitial Pulmonary Calcification

George M. Grames, Donald D. Sauser, Carl Jansen, Robert E. Soderblom, John E. Hodgkin, Mildred S. Stilson

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Two patients who had hypercalcemia, one from multiple myeloma and the other from metastatic carcinoma, showed striking concentrations of bone-seeking radiopharmaceuticals in the lungs on routine bone scans. Neither patient had roentgenographic evidence of intrapulmonary calcification. Histologic examination in one patient showed extensive interstitial pulmonary calcification. These cases dramatically illustrate the capability of radionuclides to detect interstitial pulmonary calcification when radiographic demonstration is lacking. The early detection of extraskeletal calcification by bone-seeking radionuclides provides a unique opportunity, not previously available, to study metastatic calcification and the effects of treatment.

Original languageEnglish (US)
Pages (from-to)992-995
Number of pages4
JournalJAMA: The Journal of the American Medical Association
Issue number7
StatePublished - Nov 18 1974
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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