Rapid nuclear actions of growth hormone

P. Rotwein, A. M. Granowski, M. J. Thomas

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


The mechanisms by which growth hormone (GH) initiates its effect on growth are largely unknown. In this report we examine the acute actions of GH with a focus on the intracellular signaling pathways leading from the cell-surface GH receptor into the nucleus, and culminating in the activation of specific target genes. We show that in vivo GH treatment leads to the rapid appearance of tyrosine-phosphorylated nuclear proteins and the equally rapid induction of c-fos and insulin-like growth factor I gene transcription. A model is proposed for a GH-activated intracellular signal transduction pathway.

Original languageEnglish (US)
Pages (from-to)170-175
Number of pages6
JournalHormone Research
Issue number4-5
StatePublished - 1994
Externally publishedYes


  • Gene regulation
  • Hormone action
  • Insulin-like growth factor I
  • STAT91
  • c-fos

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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