RBC lithium transport in the psychoses

Robert Hitzemann; Cynthia Mark; Jack Hirschowitz; David Garver

doi:10.1016/0006-3223(89)90177-7

RBC lithium transport in the psychoses

Robert Hitzemann
, Cynthia Mark
, Jack Hirschowitz
, David Garver

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

In vitro and in vivo red blood cell (RBC) lithium (Li ⁺ ) intracellularlextracellular ratios were determined in 93 DSM-III schizophrenics (SCZ) in 47 DSM-III schizophreniform disorder patients (SF), in 22 DSM-III bipolar manies (M), in 15 affective disorders patients with mood-incongruent psychotic features (AD-MIP), and in 40 normal controls. There were no significant differences among groups in the in vitro Li⁺ ratio. Similarly, there was no significant difference among patient groups in the in vivo Li⁺ ratio. Furthermore, there was no significant difference in the mean Li⁺ ratios between the Li⁺ -responsive and nonresponsive schizophrenic-like subjects. However, the distribution of Li⁺ ratios (both in vitro and in vivo) in the Li⁺ -responsive group was significantly abnormal, showing more ratios in the extremes of the distribution (a platykurtic distribution).

Original language	English (US)
Pages (from-to)	296-304
Number of pages	9
Journal	Biological Psychiatry
Volume	25
Issue number	3
DOIs	https://doi.org/10.1016/0006-3223(89)90177-7
State	Published - Feb 1 1989
Externally published	Yes

Funding

From the Depertment of Psychiatry and Behavioral Sciences, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, New York 11794-8101 and the Psychiatry Service, VA Medical Center, Northport, (R.H., J.H.), and the Depatment of Psychiatry, University of Cincinnati, Cincinnati, OH (C.M.. D.G.). Supported in part by a grant from the Scottish Rite Schizophrenia Foundation and NIMH Grant MH-32777. Address reprint requests to Dr. Robert J. Hitzemann, SUNY at Stony Bmok, Health Sciences Center T-10, Stony Break, NY 11974-8101. Received December 26, 1987; revised March 11, 1988.

Funders	Funder number
National Institutes of Health National Institute of Mental Health	MH-32777
Scottish Rite Charitable Foundation of Canada

ASJC Scopus subject areas

Biological Psychiatry

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10.1016/0006-3223(89)90177-7

Cite this

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title = "RBC lithium transport in the psychoses",

abstract = "In vitro and in vivo red blood cell (RBC) lithium (Li + ) intracellularlextracellular ratios were determined in 93 DSM-III schizophrenics (SCZ) in 47 DSM-III schizophreniform disorder patients (SF), in 22 DSM-III bipolar manies (M), in 15 affective disorders patients with mood-incongruent psychotic features (AD-MIP), and in 40 normal controls. There were no significant differences among groups in the in vitro Li+ ratio. Similarly, there was no significant difference among patient groups in the in vivo Li+ ratio. Furthermore, there was no significant difference in the mean Li+ ratios between the Li+ -responsive and nonresponsive schizophrenic-like subjects. However, the distribution of Li+ ratios (both in vitro and in vivo) in the Li+ -responsive group was significantly abnormal, showing more ratios in the extremes of the distribution (a platykurtic distribution).",

author = "Robert Hitzemann and Cynthia Mark and Jack Hirschowitz and David Garver",

note = "Funding Information: From the Depertment of Psychiatry and Behavioral Sciences, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, New York 11794-8101 and the Psychiatry Service, VA Medical Center, Northport, (R.H., J.H.), and the Depatment of Psychiatry, University of Cincinnati, Cincinnati, OH (C.M.. D.G.). Supported in part by a grant from the Scottish Rite Schizophrenia Foundation and NIMH Grant MH-32777. Address reprint requests to Dr. Robert J. Hitzemann, SUNY at Stony Bmok, Health Sciences Center T-10, Stony Break, NY 11974-8101. Received December 26, 1987; revised March 11, 1988.",

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AU - Hirschowitz, Jack

AU - Garver, David

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PY - 1989/2/1

Y1 - 1989/2/1

N2 - In vitro and in vivo red blood cell (RBC) lithium (Li + ) intracellularlextracellular ratios were determined in 93 DSM-III schizophrenics (SCZ) in 47 DSM-III schizophreniform disorder patients (SF), in 22 DSM-III bipolar manies (M), in 15 affective disorders patients with mood-incongruent psychotic features (AD-MIP), and in 40 normal controls. There were no significant differences among groups in the in vitro Li+ ratio. Similarly, there was no significant difference among patient groups in the in vivo Li+ ratio. Furthermore, there was no significant difference in the mean Li+ ratios between the Li+ -responsive and nonresponsive schizophrenic-like subjects. However, the distribution of Li+ ratios (both in vitro and in vivo) in the Li+ -responsive group was significantly abnormal, showing more ratios in the extremes of the distribution (a platykurtic distribution).

AB - In vitro and in vivo red blood cell (RBC) lithium (Li + ) intracellularlextracellular ratios were determined in 93 DSM-III schizophrenics (SCZ) in 47 DSM-III schizophreniform disorder patients (SF), in 22 DSM-III bipolar manies (M), in 15 affective disorders patients with mood-incongruent psychotic features (AD-MIP), and in 40 normal controls. There were no significant differences among groups in the in vitro Li+ ratio. Similarly, there was no significant difference among patient groups in the in vivo Li+ ratio. Furthermore, there was no significant difference in the mean Li+ ratios between the Li+ -responsive and nonresponsive schizophrenic-like subjects. However, the distribution of Li+ ratios (both in vitro and in vivo) in the Li+ -responsive group was significantly abnormal, showing more ratios in the extremes of the distribution (a platykurtic distribution).

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ER -

RBC lithium transport in the psychoses

Abstract

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