TY - JOUR
T1 - Recent advances in alveolar biology
T2 - Some new looks at the alveolar interface
AU - Possmayer, Fred
AU - Hall, Stephen B.
AU - Haller, Thomas
AU - Petersen, Nils O.
AU - Zuo, Yi Y.
AU - Bernardino de la Serna, Jorge
AU - Postle, Anthony D.
AU - Veldhuizen, Ruud A.W.
AU - Orgeig, Sandra
PY - 2010/9
Y1 - 2010/9
N2 - This article examines the manner in which some new methodologies and novel concepts have contributed to our understanding of how pulmonary surfactant reduces alveolar surface tension. Investigations utilizing small angle X-ray diffraction, inverted interface fluorescence microscopy, time of flight-secondary ion mass spectroscopy, atomic force microscopy, two-photon fluorescence microscopy and electrospray mass spectroscopy are highlighted and a new model of ventilation-induced acute lung injury described. This contribution attempts to emphasize how these new approaches have resulted in a fuller appreciation of events presumably occurring at the alveolar interface.
AB - This article examines the manner in which some new methodologies and novel concepts have contributed to our understanding of how pulmonary surfactant reduces alveolar surface tension. Investigations utilizing small angle X-ray diffraction, inverted interface fluorescence microscopy, time of flight-secondary ion mass spectroscopy, atomic force microscopy, two-photon fluorescence microscopy and electrospray mass spectroscopy are highlighted and a new model of ventilation-induced acute lung injury described. This contribution attempts to emphasize how these new approaches have resulted in a fuller appreciation of events presumably occurring at the alveolar interface.
KW - Acute respiratory distress
KW - Fluorescence microscopy
KW - Mass spectroscopy
KW - Phospholipid metabolism
KW - Pulmonary surfactant
KW - X-ray diffraction
UR - http://www.scopus.com/inward/record.url?scp=77955652843&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77955652843&partnerID=8YFLogxK
U2 - 10.1016/j.resp.2010.02.014
DO - 10.1016/j.resp.2010.02.014
M3 - Review article
C2 - 20206718
AN - SCOPUS:77955652843
SN - 1569-9048
VL - 173
SP - S55-S64
JO - Respiratory Physiology and Neurobiology
JF - Respiratory Physiology and Neurobiology
IS - SUPPL.
ER -