Recombinant human platelet-derived growth factor-BB in human alveolar ridge augmentation: A review of the literature

Cynthia Scheines; Steven D. Hokett; James A. Katancik

doi:10.11607/jomi.6292

Recombinant human platelet-derived growth factor-BB in human alveolar ridge augmentation: A review of the literature

Cynthia Scheines, Steven D. Hokett, James A. Katancik

School of Dentistry

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Purpose: The objective of this study was to review the available literature regarding the use of recombinant human platelet-derived growth factor-BB (rhPDGF-BB) in human alveolar ridge augmentation and to assess its effectiveness for this specific use. Materials and Methods: Three electronic searches of the MEDLINE database were performed. Results: This review noted a wide range of study protocols, carrier systems, study periods, and outcome measures. Conclusion: Within the limits of this literature review, the use of rhPDGF-BB and bone regeneration/ridge augmentation led to greater clinical attachment level gain and bone regeneration prior to implant placement. More controlled clinical studies are needed to establish the effectiveness of rhPDGF-BB in alveolar ridge augmentation.

Original language	English (US)
Pages (from-to)	1047-1056
Number of pages	10
Journal	International Journal of Oral and Maxillofacial Implants
Volume	33
Issue number	5
DOIs	https://doi.org/10.11607/jomi.6292
State	Published - 2018

Keywords

Bone regeneration
Recombinant platelet-derived growth factor BB
RhPDGF-BB
alveolar ridge augmentation

ASJC Scopus subject areas

Oral Surgery

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10.11607/jomi.6292

Cite this

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title = "Recombinant human platelet-derived growth factor-BB in human alveolar ridge augmentation: A review of the literature",

abstract = "Purpose: The objective of this study was to review the available literature regarding the use of recombinant human platelet-derived growth factor-BB (rhPDGF-BB) in human alveolar ridge augmentation and to assess its effectiveness for this specific use. Materials and Methods: Three electronic searches of the MEDLINE database were performed. Results: This review noted a wide range of study protocols, carrier systems, study periods, and outcome measures. Conclusion: Within the limits of this literature review, the use of rhPDGF-BB and bone regeneration/ridge augmentation led to greater clinical attachment level gain and bone regeneration prior to implant placement. More controlled clinical studies are needed to establish the effectiveness of rhPDGF-BB in alveolar ridge augmentation.",

keywords = "Bone regeneration, Recombinant platelet-derived growth factor BB, RhPDGF-BB, alveolar ridge augmentation",

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year = "2018",

doi = "10.11607/jomi.6292",

language = "English (US)",

volume = "33",

pages = "1047--1056",

journal = "International Journal of Oral and Maxillofacial Implants",

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T1 - Recombinant human platelet-derived growth factor-BB in human alveolar ridge augmentation

T2 - A review of the literature

AU - Scheines, Cynthia

AU - Hokett, Steven D.

AU - Katancik, James A.

PY - 2018

Y1 - 2018

N2 - Purpose: The objective of this study was to review the available literature regarding the use of recombinant human platelet-derived growth factor-BB (rhPDGF-BB) in human alveolar ridge augmentation and to assess its effectiveness for this specific use. Materials and Methods: Three electronic searches of the MEDLINE database were performed. Results: This review noted a wide range of study protocols, carrier systems, study periods, and outcome measures. Conclusion: Within the limits of this literature review, the use of rhPDGF-BB and bone regeneration/ridge augmentation led to greater clinical attachment level gain and bone regeneration prior to implant placement. More controlled clinical studies are needed to establish the effectiveness of rhPDGF-BB in alveolar ridge augmentation.

AB - Purpose: The objective of this study was to review the available literature regarding the use of recombinant human platelet-derived growth factor-BB (rhPDGF-BB) in human alveolar ridge augmentation and to assess its effectiveness for this specific use. Materials and Methods: Three electronic searches of the MEDLINE database were performed. Results: This review noted a wide range of study protocols, carrier systems, study periods, and outcome measures. Conclusion: Within the limits of this literature review, the use of rhPDGF-BB and bone regeneration/ridge augmentation led to greater clinical attachment level gain and bone regeneration prior to implant placement. More controlled clinical studies are needed to establish the effectiveness of rhPDGF-BB in alveolar ridge augmentation.

KW - Bone regeneration

KW - Recombinant platelet-derived growth factor BB

KW - RhPDGF-BB

KW - alveolar ridge augmentation

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Recombinant human platelet-derived growth factor-BB in human alveolar ridge augmentation: A review of the literature

Abstract

Keywords

ASJC Scopus subject areas

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