Recurrent melanoma arising from sclera

Hillary C. Stiefel, Audra Miller, David J. Wilson, Daniel M. Albert

Research output: Contribution to journalArticlepeer-review


Purpose: To report a case of recurrent malignant melanoma suspected to have arisen from intrascleral melanocytic cells. Observations: En bloc removal of melanoma was performed with iridocyclectomy in a 46-year-old Caucasian male. Histopathologic examination confirmed a diagnosis of malignant melanoma in the subconjunctival space, which was presumed to have arisen from the sclera and extended both intraocularly and subconjunctivally. 15 years later, a pigmented limbal lesion near the site of the previous iridocyclectomy was excised by lamellar sclerectomy. Histopathology showed a proliferation of pigment-containing cells with atypical nuclei consistent with recurrent melanoma. Conclusions and Importance: We report a case of recurrent melanoma that we suspect arose from intrascleral melanocytes, extended both intraocularly and subconjunctivally, and recurred 15 years following initial excision.

Original languageEnglish (US)
Article number101562
JournalAmerican Journal of Ophthalmology Case Reports
StatePublished - Sep 2022


  • Iridocyclectomy
  • Ocular melanoma
  • Recurrent melanoma
  • Scleral melanoma

ASJC Scopus subject areas

  • Ophthalmology


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