Reevaluating goals of insulin therapy: Perspectives from large clinical trials

Matthew C. Riddle, Kevin C.J. Yuen

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


Recent large clinical trials have shown that intensive glycemic control can reduce microvascular complications, but appropriate and safe glycemic goals to improve macrovascular outcomes in patients with type 2 diabetes remain poorly defined. This article surveys recent epidemiologic studies and interventional trials, examines the current understanding of the natural history of type 2 diabetes, and proposes new goals and tactics for optimizing insulin therapy.

Original languageEnglish (US)
Pages (from-to)41-56
Number of pages16
JournalEndocrinology and Metabolism Clinics of North America
Issue number1
StatePublished - Mar 2012


  • Cardiovascular risk
  • Diabetes
  • Glycemic control
  • Goals
  • Insulin
  • Macrovascular
  • Microvascular
  • Tactics

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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