Reevaluating goals of insulin therapy: Perspectives from large clinical trials

Matthew C. Riddle; Kevin C.J. Yuen

doi:10.1016/j.ecl.2012.03.003

Reevaluating goals of insulin therapy: Perspectives from large clinical trials

Matthew C. Riddle, Kevin C.J. Yuen

Endocrinology, Diabetes and Clinical Nutrition

Research output: Contribution to journal › Review article › peer-review

8 Scopus citations

Abstract

Recent large clinical trials have shown that intensive glycemic control can reduce microvascular complications, but appropriate and safe glycemic goals to improve macrovascular outcomes in patients with type 2 diabetes remain poorly defined. This article surveys recent epidemiologic studies and interventional trials, examines the current understanding of the natural history of type 2 diabetes, and proposes new goals and tactics for optimizing insulin therapy.

Original language	English (US)
Pages (from-to)	41-56
Number of pages	16
Journal	Endocrinology and Metabolism Clinics of North America
Volume	41
Issue number	1
DOIs	https://doi.org/10.1016/j.ecl.2012.03.003
State	Published - Mar 2012

Keywords

Cardiovascular risk
Diabetes
Glycemic control
Goals
Insulin
Macrovascular
Microvascular
Tactics

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

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10.1016/j.ecl.2012.03.003

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abstract = "Recent large clinical trials have shown that intensive glycemic control can reduce microvascular complications, but appropriate and safe glycemic goals to improve macrovascular outcomes in patients with type 2 diabetes remain poorly defined. This article surveys recent epidemiologic studies and interventional trials, examines the current understanding of the natural history of type 2 diabetes, and proposes new goals and tactics for optimizing insulin therapy.",

keywords = "Cardiovascular risk, Diabetes, Glycemic control, Goals, Insulin, Macrovascular, Microvascular, Tactics",

author = "Riddle, {Matthew C.} and Yuen, {Kevin C.J.}",

note = "Funding Information: This work was supported in part by the Rose Hastings and Russell Standley Memorial Trusts . ",

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AB - Recent large clinical trials have shown that intensive glycemic control can reduce microvascular complications, but appropriate and safe glycemic goals to improve macrovascular outcomes in patients with type 2 diabetes remain poorly defined. This article surveys recent epidemiologic studies and interventional trials, examines the current understanding of the natural history of type 2 diabetes, and proposes new goals and tactics for optimizing insulin therapy.

KW - Cardiovascular risk

KW - Diabetes

KW - Glycemic control

KW - Goals

KW - Insulin

KW - Macrovascular

KW - Microvascular

KW - Tactics

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Reevaluating goals of insulin therapy: Perspectives from large clinical trials

Abstract

Keywords

ASJC Scopus subject areas

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