Regulation and action of angiogenic factors in the primate ovary

Richard L. Stouffer, Juan Carlos Martínez-Chequer, Theodore A. Molskness, Fuhua Xu, Timothy M. Hazzard

Research output: Contribution to journalReview articlepeer-review

144 Scopus citations


The ephemerality of the maturing follicle and subsequent corpus luteum as they perform their gametogenic and/or endocrine functions during the ovarian cycle is associated with remarkable changes in local vasculature. Studies on the angiogenic and angiolytic process in the ovary, rare in healthy adult tissues, complement recent efforts to understand vasculogenesis in embryonic tissues and to control angiogenesis in pathologic states such as cancer. Several reports indicate that the newly discovered vascular-specific angiogenic factors are expressed in the ovary, notably members of the vascular endothelial growth factor (VEGF) and angiopoietin (Ang) families plus their receptors (VEGF-Rs, neuropilins, Tie). Unlike in many other tissues, gonadotropic hormones (particularly luteinizing hormone, [LH]) are major stimulators of angiogenesis and VEGF/Ang expression in the ovary. However, local factors such as insulin-like growth factors or oxygen tension likely modulate the angiogenic processes. Recent studies employing systemic or local administration of anti-angiogenic drugs (TNP-470 or fumagillin) or specific VEGF antagonists (VEGF antibody or soluble VEGFR-1) demonstrate a vital role for normal angiogenesis and VEGF action in follicle development, ovulation, or corpus luteum function. Further studies discerning the various angiogenic factors and their roles in controlling the growth, maturation, function, and regression of the vasculature in ovarian compartments during the menstrual cycle could yield novel strategies for manipulating fertility or for alleviating infertility.

Original languageEnglish (US)
Pages (from-to)567-575
Number of pages9
JournalArchives of Medical Research
Issue number6
StatePublished - 2001
Externally publishedYes


  • Angiopoietin
  • Anti-angiogenic drugs
  • Vascular endothelial growth factor (VEGF)

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'Regulation and action of angiogenic factors in the primate ovary'. Together they form a unique fingerprint.

Cite this