REGULATION OF INSULIN, IGF-I, AND IGF-11 GENE EXPRESSION

Martin L. Adamo; Mark A. Bach; Charles T. Roberts; Derek LeRoith

doi:10.1201/9781003574583-10

REGULATION OF INSULIN, IGF-I, AND IGF-11 GENE EXPRESSION

Martin L. Adamo, Mark A. Bach, Charles T. Roberts, Derek LeRoith

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Insulin and insulin-like growth factor I (IGF-I) and II (IGF-II) are structurally, functionally, and genetically related. 1–3 Of the three, insulin is the classical endocrine agent. It is synthesized by and released from the pancreatic beta-cell into the circulation, and it regulates cellular metabolism in a number of target tissues. The IGFs, on the other hand, are synthesized in numerous tissues and may act locally, resulting in mitogenesis, growth promotion, insulin-like metabolic effects, and potentially other bioeffects. In addition to these paracrine and/or autocrine modes of cellular regulation, IGF-I may act as an endocrine agent when its synthesis by and release from the liver is stimulated by growth hormone (GH). The circulating IGF-I then stimulates longitudinal growth and body weight gain, thus, giving rise to the original descriptive term, somatomedin-C.

Original language	English (US)
Title of host publication	Insulin-Like Growth Factors
Subtitle of host publication	Molecular and Cellular Aspects
Publisher	CRC Press
Pages	271-303
Number of pages	33
ISBN (Electronic)	9781040294499
ISBN (Print)	9780849357121
DOIs	https://doi.org/10.1201/9781003574583-10
State	Published - Jan 1 2024
Externally published	Yes

ASJC Scopus subject areas

General Medicine
General Biochemistry, Genetics and Molecular Biology
General Agricultural and Biological Sciences

Access to Document

10.1201/9781003574583-10

Cite this

@inbook{1f72f0fdcec94369a9efdd2bd321bea4,

title = "REGULATION OF INSULIN, IGF-I, AND IGF-11 GENE EXPRESSION",

abstract = "Insulin and insulin-like growth factor I (IGF-I) and II (IGF-II) are structurally, functionally, and genetically related. 1–3 Of the three, insulin is the classical endocrine agent. It is synthesized by and released from the pancreatic beta-cell into the circulation, and it regulates cellular metabolism in a number of target tissues. The IGFs, on the other hand, are synthesized in numerous tissues and may act locally, resulting in mitogenesis, growth promotion, insulin-like metabolic effects, and potentially other bioeffects. In addition to these paracrine and/or autocrine modes of cellular regulation, IGF-I may act as an endocrine agent when its synthesis by and release from the liver is stimulated by growth hormone (GH). The circulating IGF-I then stimulates longitudinal growth and body weight gain, thus, giving rise to the original descriptive term, somatomedin-C.",

author = "Adamo, {Martin L.} and Bach, {Mark A.} and Roberts, {Charles T.} and Derek LeRoith",

note = "Publisher Copyright: {\textcopyright} 2024 CRC Press.",

year = "2024",

month = jan,

day = "1",

doi = "10.1201/9781003574583-10",

language = "English (US)",

isbn = "9780849357121",

pages = "271--303",

booktitle = "Insulin-Like Growth Factors",

publisher = "CRC Press",

}

TY - CHAP

T1 - REGULATION OF INSULIN, IGF-I, AND IGF-11 GENE EXPRESSION

AU - Adamo, Martin L.

AU - Bach, Mark A.

AU - Roberts, Charles T.

AU - LeRoith, Derek

PY - 2024/1/1

Y1 - 2024/1/1

N2 - Insulin and insulin-like growth factor I (IGF-I) and II (IGF-II) are structurally, functionally, and genetically related. 1–3 Of the three, insulin is the classical endocrine agent. It is synthesized by and released from the pancreatic beta-cell into the circulation, and it regulates cellular metabolism in a number of target tissues. The IGFs, on the other hand, are synthesized in numerous tissues and may act locally, resulting in mitogenesis, growth promotion, insulin-like metabolic effects, and potentially other bioeffects. In addition to these paracrine and/or autocrine modes of cellular regulation, IGF-I may act as an endocrine agent when its synthesis by and release from the liver is stimulated by growth hormone (GH). The circulating IGF-I then stimulates longitudinal growth and body weight gain, thus, giving rise to the original descriptive term, somatomedin-C.

AB - Insulin and insulin-like growth factor I (IGF-I) and II (IGF-II) are structurally, functionally, and genetically related. 1–3 Of the three, insulin is the classical endocrine agent. It is synthesized by and released from the pancreatic beta-cell into the circulation, and it regulates cellular metabolism in a number of target tissues. The IGFs, on the other hand, are synthesized in numerous tissues and may act locally, resulting in mitogenesis, growth promotion, insulin-like metabolic effects, and potentially other bioeffects. In addition to these paracrine and/or autocrine modes of cellular regulation, IGF-I may act as an endocrine agent when its synthesis by and release from the liver is stimulated by growth hormone (GH). The circulating IGF-I then stimulates longitudinal growth and body weight gain, thus, giving rise to the original descriptive term, somatomedin-C.

UR - http://www.scopus.com/inward/record.url?scp=85213933137&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85213933137&partnerID=8YFLogxK

U2 - 10.1201/9781003574583-10

DO - 10.1201/9781003574583-10

M3 - Chapter

AN - SCOPUS:85213933137

SN - 9780849357121

SP - 271

EP - 303

BT - Insulin-Like Growth Factors

PB - CRC Press

ER -

REGULATION OF INSULIN, IGF-I, AND IGF-11 GENE EXPRESSION

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this