Regulation of synaptic timing in the olfactory bulb by an A-type potassium current

N. E. Schoppa; G. L. Westbrook

doi:10.1038/16033

Regulation of synaptic timing in the olfactory bulb by an A-type potassium current

N. E. Schoppa
, G. L. Westbrook

Vollum Institute

Research output: Contribution to journal › Article › peer-review

183 Scopus citations

Abstract

Although rapid synaptic transmission confers signal fidelity, the activity of some neuronal circuits depends on prolonged excitation or inhibition. Here we demonstrate that GABAergic granule cells in the rat olfactory bulb produce prolonged inhibition of mitral cells through a precise kinetic matching between transmitter-gated and voltage-gated channels in their dendritic membrane. A transient A-type potassium current (I(A)) specifically attenuated dendrodendritic inputs mediated by fast-acting AMPA receptors such that the excitation and subsequent inhibitory output of granule cells followed the prolonged kinetics of their NMDA receptors. Altering the weights of the AMPA and NMDA receptor-mediated inputs by modulating I(A) provides a mechanism to regulate the timing of inhibition according to the demands on the bulb network.

Original language	English (US)
Pages (from-to)	1106-1113
Number of pages	8
Journal	Nature Neuroscience
Volume	2
Issue number	12
DOIs	https://doi.org/10.1038/16033
State	Published - Dec 1999

Funding

This work was supported by National Institute of Health grants 5F32 DC00270 to NES and NS26494 to GLW. We thank John Adelman for helpful comments on the manuscript.

Funders	Funder number
National Institute of Health National Eye Institute	5F32 DC00270
National Institute of Neurological Disorders and Stroke	R29NS026494

ASJC Scopus subject areas

General Neuroscience

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title = "Regulation of synaptic timing in the olfactory bulb by an A-type potassium current",

abstract = "Although rapid synaptic transmission confers signal fidelity, the activity of some neuronal circuits depends on prolonged excitation or inhibition. Here we demonstrate that GABAergic granule cells in the rat olfactory bulb produce prolonged inhibition of mitral cells through a precise kinetic matching between transmitter-gated and voltage-gated channels in their dendritic membrane. A transient A-type potassium current (I(A)) specifically attenuated dendrodendritic inputs mediated by fast-acting AMPA receptors such that the excitation and subsequent inhibitory output of granule cells followed the prolonged kinetics of their NMDA receptors. Altering the weights of the AMPA and NMDA receptor-mediated inputs by modulating I(A) provides a mechanism to regulate the timing of inhibition according to the demands on the bulb network.",

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N2 - Although rapid synaptic transmission confers signal fidelity, the activity of some neuronal circuits depends on prolonged excitation or inhibition. Here we demonstrate that GABAergic granule cells in the rat olfactory bulb produce prolonged inhibition of mitral cells through a precise kinetic matching between transmitter-gated and voltage-gated channels in their dendritic membrane. A transient A-type potassium current (I(A)) specifically attenuated dendrodendritic inputs mediated by fast-acting AMPA receptors such that the excitation and subsequent inhibitory output of granule cells followed the prolonged kinetics of their NMDA receptors. Altering the weights of the AMPA and NMDA receptor-mediated inputs by modulating I(A) provides a mechanism to regulate the timing of inhibition according to the demands on the bulb network.

AB - Although rapid synaptic transmission confers signal fidelity, the activity of some neuronal circuits depends on prolonged excitation or inhibition. Here we demonstrate that GABAergic granule cells in the rat olfactory bulb produce prolonged inhibition of mitral cells through a precise kinetic matching between transmitter-gated and voltage-gated channels in their dendritic membrane. A transient A-type potassium current (I(A)) specifically attenuated dendrodendritic inputs mediated by fast-acting AMPA receptors such that the excitation and subsequent inhibitory output of granule cells followed the prolonged kinetics of their NMDA receptors. Altering the weights of the AMPA and NMDA receptor-mediated inputs by modulating I(A) provides a mechanism to regulate the timing of inhibition according to the demands on the bulb network.

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Regulation of synaptic timing in the olfactory bulb by an A-type potassium current

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