Regulation of triglyceride metabolism by glucocorticoid receptor

Jen Chywan Wang, Nora E. Gray, Taiyi Kuo, Charles A. Harris

Research output: Contribution to journalReview articlepeer-review

51 Scopus citations


Glucocorticoids are steroid hormones that play critical and complex roles in the regulation of triglyceride (TG) homeostasis. Depending on physiological states, glucocorticoids can modulate both TG synthesis and hydrolysis. More intriguingly, glucocorticoids can concurrently affect these two processes in adipocytes. The metabolic effects of glucocorticoids are conferred by intracellular glucocorticoid receptors (GR). GR is a transcription factor that, upon binding to glucocorticoids, regulates the transcriptional rate of specific genes. These GR primary target genes further initiate the physiological and pathological responses of glucocorticoids. In this article, we overview glucocorticoid-regulated genes, especially those potential GR primary target genes, involved in glucocorticoid-regulated TG metabolism. We also discuss transcriptional regulators that could act with GR to participate in these processes. This knowledge is not only important for the fundamental understanding of steroid hormone actions, but also are essential for future therapeutic interventions against metabolic diseases associated with aberrant glucocorticoid signaling, such as insulin resistance, dyslipidemia, central obesity and hepatic steatosis.

Original languageEnglish (US)
Article number19
JournalCell and Bioscience
Issue number1
StatePublished - May 28 2012
Externally publishedYes


  • Glucocorticoid
  • Glucocorticoid receptor
  • Glucocorticoid response element
  • Lipogenesis
  • Lipolysis
  • Transcription
  • Triglyceride

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


Dive into the research topics of 'Regulation of triglyceride metabolism by glucocorticoid receptor'. Together they form a unique fingerprint.

Cite this