TY - JOUR
T1 - Relationship of cytomegalovirus to salivary gland dysfunction in HIV-infected patients
AU - Greenberg, Martin S.
AU - Glick, Michael
AU - Nghiem, Lan
AU - Stewart, Jeffrey C.B.
AU - Hodinka, Richard
AU - Dubin, Gary
N1 - Funding Information:
Cytomegalovirus (CMV) is an important cause of morbidity and mortality in immtmocompromised persons such as patients taking immunosuppressive Supported by University Research Foundation no. 2555-0 and in part by USPHS Research Grant M01-RR00040, National Institutes of Health. aprofessor and Chairman of Oral Medicine and Associate Dean of Hospital Affairs University of Pennsylvania School of Dental Medicine; Chief of Oral Medicine and Hospital Dentistpj, Hospital of the University of Pennsylvania. bAssociate Professor of Oral Medicine and Director of Infectious Disease Clinic, Department of Oral Medicine, University of Pennsylvania School of Dental Medicine. CResearch Specialist, Division of Infectious Diseases, University of Pennsylvania School of Medicine. dAssistant Professor of Pathology, University of Pennsylvania School of Dental Medicine. eDirector of Clinical Virology Lab, Departments of Pathology and Pediatrics, Children's Hospital of Philadelphia and University of Pennsylvania School of Medicine. fAssistant Professor of Medicine, University of Pennsylvania School of Medicine; Present address: SmithKline-Beecham Pharmaceuticals Clinical Research and Development, Antiinfectives/ Biologicals, Collegeville, Pa. Received for publication May 8, 1996; returned for revision June 5, 1996; accepted for publication Aug. 16, 1996. Copyright © 1997 by Mosby-Year Book, Inc. 1079-2104/97/$5.00 + 0 7/13/77577 drugs, 1,3 cancer chemotherapy? or patients infected with HIV. 4, 5 CMV-related complications commonly observed in patients with HIV include retinitis, encephalitis, hepatitis, gastrointestinal ulcers, and leukopenia. CMV has also been described as a cause of oral mucosal ulcers in patients with advanced AIDS. In a recent study by Flaitz et al. 6 regarding persistent oral mucosal ulcers in HIV-infected patients, CMV was associated with over 50% of the lesions.
PY - 1997
Y1 - 1997
N2 - In a previous retrospective study of HIV-infected patients we detected a relationship between xerostomia and the presence of cytomegalovirus in saliva. This prospective study compares 13 patients with HIV and a complaint of xerostomia and low salivary flow rates with a control group of 7 patients with HIV without xerostomia and normal salivary flow rates. Both groups were evaluated for the presence of cytomegalovirus in saliva, peripheral blood mononuclear cells, and labial minor salivary glands. Viral cultures, polymerase chain reaction, and histopathologic examination were used to detect cytomegalovirus. Xerostomia and low salivary flow rates were associated with the presence of CMV in saliva. The virus was detected in 10 of 13 xerostomia patients and 2 of 7 controls (p = 0.05, Fisher's exact test). Cytomegalovirus was detected in the saliva of patients who did not also have it in their blood suggesting a local source of virus replication such as the salivary glands. The minor salivary glands were not a major site of cytomegalovirus. Culture was more sensitive then polymerase chain reaction in detecting salivary cytomegalovirus as a result of the presence of inhibitors to the reaction in saliva. These results suggest a link between cytomegalovirus in saliva and salivary gland dysfunction in HIV-infected patients.
AB - In a previous retrospective study of HIV-infected patients we detected a relationship between xerostomia and the presence of cytomegalovirus in saliva. This prospective study compares 13 patients with HIV and a complaint of xerostomia and low salivary flow rates with a control group of 7 patients with HIV without xerostomia and normal salivary flow rates. Both groups were evaluated for the presence of cytomegalovirus in saliva, peripheral blood mononuclear cells, and labial minor salivary glands. Viral cultures, polymerase chain reaction, and histopathologic examination were used to detect cytomegalovirus. Xerostomia and low salivary flow rates were associated with the presence of CMV in saliva. The virus was detected in 10 of 13 xerostomia patients and 2 of 7 controls (p = 0.05, Fisher's exact test). Cytomegalovirus was detected in the saliva of patients who did not also have it in their blood suggesting a local source of virus replication such as the salivary glands. The minor salivary glands were not a major site of cytomegalovirus. Culture was more sensitive then polymerase chain reaction in detecting salivary cytomegalovirus as a result of the presence of inhibitors to the reaction in saliva. These results suggest a link between cytomegalovirus in saliva and salivary gland dysfunction in HIV-infected patients.
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U2 - 10.1016/S1079-2104(97)90239-0
DO - 10.1016/S1079-2104(97)90239-0
M3 - Article
C2 - 9084195
AN - SCOPUS:0031087066
SN - 2212-4403
VL - 83
SP - 334
EP - 339
JO - Oral Surgery Oral Medicine and Oral Pathology
JF - Oral Surgery Oral Medicine and Oral Pathology
IS - 3
ER -