TY - JOUR
T1 - Relationship of oral disease to the presence of cytomegalovirus DNA in the saliva of AIDS patients
AU - Greenberg, Martin S.
AU - Dubin, Gary
AU - Stewart, Jeffery C.B.
AU - Cumming, Christopher G.
AU - MacGregor, Rob Roy
AU - Friedman, Harvey M.
N1 - Funding Information:
Supported by University of Pennsylvania Research Foundation Procotol No. 2550-0 and the NCRR-GCRC No. RR00040. aprofessor and Chairman, Department of Oral Medicine, School of Dental Medicine. bAssistant Professor, Division of Infectious Diseases, School of Medicine. CAssistant Professor, Department of Pathology, School of Dental Medicine. dprofessor and Chairman, Department of Diagnosis Sciences, University of Missouri-Kansas City, School of Dentistry. eProfessor, Division of Infectious Diseases, School of Medicine. fProfessor and Chief, Division of Infectious Diseases, School of Medicine. Copyright | 1995 by Mosby-Year Book, Inc. 1079-2104/95/$3.00 + 0 7/13/60620
PY - 1995/2
Y1 - 1995/2
N2 - Cytomegalovirus is an important pathogen in persons infected with human immunodeficiency virus. In this study a thorough oral examination was done and blood and urine cultures for cytomegalovirus were obtained from a group of 31 patients with acquired immunodeficiency syndrome with CD4 lymphocyte counts less than 150 cells/mm3. Whole saliva was also collected for detection of cytomegalovirus deoxyribonucleic acid (DNA) via the polymerase chain reaction. The presence of cytomegalovirus DNA in the saliva specimens was not related to the presence of cytomegalovirus in the urine, which suggests a local source of cytomegalovirus from salivary gland and kidney parenchyma. There was also a strong statistical relationship between salivary cytomegalovirus DNA and xerostomia (p=0.0004), which suggests that cytomegalovirus may be a cause of salivary gland dysfunction in patients with acquired immunodeficiency syndrome with low CD4 counts.
AB - Cytomegalovirus is an important pathogen in persons infected with human immunodeficiency virus. In this study a thorough oral examination was done and blood and urine cultures for cytomegalovirus were obtained from a group of 31 patients with acquired immunodeficiency syndrome with CD4 lymphocyte counts less than 150 cells/mm3. Whole saliva was also collected for detection of cytomegalovirus deoxyribonucleic acid (DNA) via the polymerase chain reaction. The presence of cytomegalovirus DNA in the saliva specimens was not related to the presence of cytomegalovirus in the urine, which suggests a local source of cytomegalovirus from salivary gland and kidney parenchyma. There was also a strong statistical relationship between salivary cytomegalovirus DNA and xerostomia (p=0.0004), which suggests that cytomegalovirus may be a cause of salivary gland dysfunction in patients with acquired immunodeficiency syndrome with low CD4 counts.
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U2 - 10.1016/S1079-2104(05)80278-1
DO - 10.1016/S1079-2104(05)80278-1
M3 - Article
C2 - 7614180
AN - SCOPUS:0029242263
SN - 1079-2104
VL - 79
SP - 175
EP - 179
JO - Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and
JF - Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and
IS - 2
ER -