Relationship of oral disease to the presence of cytomegalovirus DNA in the saliva of AIDS patients

Martin S. Greenberg; Gary Dubin; Jeffery C.B. Stewart; Christopher G. Cumming; Rob Roy MacGregor; Harvey M. Friedman

doi:10.1016/S1079-2104(05)80278-1

Relationship of oral disease to the presence of cytomegalovirus DNA in the saliva of AIDS patients

Martin S. Greenberg
, Gary Dubin
, Jeffery C.B. Stewart
, Christopher G. Cumming
, Rob Roy MacGregor
, Harvey M. Friedman

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Cytomegalovirus is an important pathogen in persons infected with human immunodeficiency virus. In this study a thorough oral examination was done and blood and urine cultures for cytomegalovirus were obtained from a group of 31 patients with acquired immunodeficiency syndrome with CD4 lymphocyte counts less than 150 cells/mm³. Whole saliva was also collected for detection of cytomegalovirus deoxyribonucleic acid (DNA) via the polymerase chain reaction. The presence of cytomegalovirus DNA in the saliva specimens was not related to the presence of cytomegalovirus in the urine, which suggests a local source of cytomegalovirus from salivary gland and kidney parenchyma. There was also a strong statistical relationship between salivary cytomegalovirus DNA and xerostomia (p=0.0004), which suggests that cytomegalovirus may be a cause of salivary gland dysfunction in patients with acquired immunodeficiency syndrome with low CD4 counts.

Original language	English (US)
Pages (from-to)	175-179
Number of pages	5
Journal	Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
Volume	79
Issue number	2
DOIs	https://doi.org/10.1016/S1079-2104(05)80278-1
State	Published - Feb 1995
Externally published	Yes

Funding

Supported by University of Pennsylvania Research Foundation Procotol No. 2550-0 and the NCRR-GCRC No. RR00040. aprofessor and Chairman, Department of Oral Medicine, School of Dental Medicine. bAssistant Professor, Division of Infectious Diseases, School of Medicine. CAssistant Professor, Department of Pathology, School of Dental Medicine. dprofessor and Chairman, Department of Diagnosis Sciences, University of Missouri-Kansas City, School of Dentistry. eProfessor, Division of Infectious Diseases, School of Medicine. fProfessor and Chief, Division of Infectious Diseases, School of Medicine. Copyright | 1995 by Mosby-Year Book, Inc. 1079-2104/95/$3.00 + 0 7/13/60620

Funders	Funder number
NIH/NCRR/GCRC
University of Pennsylvania Research Foundation	2550-0

ASJC Scopus subject areas

Surgery
Oral Surgery
Otorhinolaryngology
General Dentistry

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10.1016/S1079-2104(05)80278-1

Cite this

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title = "Relationship of oral disease to the presence of cytomegalovirus DNA in the saliva of AIDS patients",

abstract = "Cytomegalovirus is an important pathogen in persons infected with human immunodeficiency virus. In this study a thorough oral examination was done and blood and urine cultures for cytomegalovirus were obtained from a group of 31 patients with acquired immunodeficiency syndrome with CD4 lymphocyte counts less than 150 cells/mm3. Whole saliva was also collected for detection of cytomegalovirus deoxyribonucleic acid (DNA) via the polymerase chain reaction. The presence of cytomegalovirus DNA in the saliva specimens was not related to the presence of cytomegalovirus in the urine, which suggests a local source of cytomegalovirus from salivary gland and kidney parenchyma. There was also a strong statistical relationship between salivary cytomegalovirus DNA and xerostomia (p=0.0004), which suggests that cytomegalovirus may be a cause of salivary gland dysfunction in patients with acquired immunodeficiency syndrome with low CD4 counts.",

author = "Greenberg, \{Martin S.\} and Gary Dubin and Stewart, \{Jeffery C.B.\} and Cumming, \{Christopher G.\} and MacGregor, \{Rob Roy\} and Friedman, \{Harvey M.\}",

note = "Funding Information: Supported by University of Pennsylvania Research Foundation Procotol No. 2550-0 and the NCRR-GCRC No. RR00040. aprofessor and Chairman, Department of Oral Medicine, School of Dental Medicine. bAssistant Professor, Division of Infectious Diseases, School of Medicine. CAssistant Professor, Department of Pathology, School of Dental Medicine. dprofessor and Chairman, Department of Diagnosis Sciences, University of Missouri-Kansas City, School of Dentistry. eProfessor, Division of Infectious Diseases, School of Medicine. fProfessor and Chief, Division of Infectious Diseases, School of Medicine. Copyright | 1995 by Mosby-Year Book, Inc. 1079-2104/95/\$3.00 + 0 7/13/60620",

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Relationship of oral disease to the presence of cytomegalovirus DNA in the saliva of AIDS patients

Abstract

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ASJC Scopus subject areas

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