Remodeling of the insect nervous system

Richard B. Levine, David B. Morton, Linda L. Restifo

Research output: Contribution to journalArticlepeer-review

112 Scopus citations


Our nervous systems and behavior are shaped by hormonally driven developmental changes that continue beyond the embryonic period. Key insights into this process have emerged from studies of the insect nervous system. During insect metamorphosis, the nervous system is remodeled through postembryonic neurogenesis, programmed cell death and the modification of persistent neurons. These changes are regulated to a large degree by gene cascades that are triggered by steroid hormones, the ecdysteroids. Current studies are attempting to reveal the molecular mechanisms involved in regulating these dramatic examples of developmental plasticity.

Original languageEnglish (US)
Pages (from-to)28-35
Number of pages8
JournalCurrent Opinion in Neurobiology
Issue number1
StatePublished - Feb 1995
Externally publishedYes

ASJC Scopus subject areas

  • General Neuroscience


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