TY - JOUR
T1 - Remodeling plans for cellular specialization
T2 - unique styles for every room
AU - Kaeser, Matthias D.
AU - Emerson, Beverly M.
N1 - Funding Information:
This work was supported by grants from the National Institutes of Health to BME, and the Swiss National Science Foundation to MDK. We apologize to our colleagues whose work was not cited owing to space limitations.
PY - 2006/10
Y1 - 2006/10
N2 - Chromatin-remodeling complexes are biochemically diverse, functionally selective machines that regulate crucial aspects of DNA metabolism, including transcription and chromatin assembly. These complexes modulate histone-DNA interactions to affect nucleosome repositioning and disassembly, and histone variant exchange, thereby generating compositionally specialized chromatin. Recent studies have revealed precise mechanisms by which specific remodelers control the transition from proliferating progenitors to committed cells through a highly synchronized switch in transcriptional programs. This involves temporal and, often, signal-dependent gene-targeted interactions between individual remodelers and tissue-specific master proteins that regulate myogenesis, neurogenesis and lymphogenesis. Distinct remodelers have also been shown to direct self-renewal of different types of stem cells in response to particular microenvironments.
AB - Chromatin-remodeling complexes are biochemically diverse, functionally selective machines that regulate crucial aspects of DNA metabolism, including transcription and chromatin assembly. These complexes modulate histone-DNA interactions to affect nucleosome repositioning and disassembly, and histone variant exchange, thereby generating compositionally specialized chromatin. Recent studies have revealed precise mechanisms by which specific remodelers control the transition from proliferating progenitors to committed cells through a highly synchronized switch in transcriptional programs. This involves temporal and, often, signal-dependent gene-targeted interactions between individual remodelers and tissue-specific master proteins that regulate myogenesis, neurogenesis and lymphogenesis. Distinct remodelers have also been shown to direct self-renewal of different types of stem cells in response to particular microenvironments.
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U2 - 10.1016/j.gde.2006.08.001
DO - 10.1016/j.gde.2006.08.001
M3 - Review article
C2 - 16905306
AN - SCOPUS:33748439688
SN - 0959-437X
VL - 16
SP - 508
EP - 512
JO - Current Opinion in Genetics and Development
JF - Current Opinion in Genetics and Development
IS - 5
ER -