Renal protection strategies in the perioperative period

Per Olof Jarnberg

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


The development of acute renal failure (ARF) in the perioperative period continues to be a vexing condition associated with high morbidity and mortality rates which have been unchanged for several decades. In this article I briefly review recent research categorizing pathogenesis of ARF and mechanisms of recovery. Once ARF is established, its maintenance phase is dependent on several mechanisms that interact with cellular integrity. The main focus of the article is on assessing clinical and experimental interventions to prevent ARF. Unfortunately, existing pharmacological and other interventions show a rather limited efficacy in preventing ARF.

Original languageEnglish (US)
Pages (from-to)645-660
Number of pages16
JournalBest Practice and Research: Clinical Anaesthesiology
Issue number4
StatePublished - Dec 2004


  • ANP
  • Acetylcysteine
  • Acute/pathophysiology/drug therapy
  • Apoptosis
  • Calcium channel blockers
  • Contrast media
  • Dopamine
  • Fenoldopam
  • Fluid therapy
  • Furosemide
  • Growth factors
  • Human
  • Ischaemic preconditioning
  • Kidney failure
  • Mannitol
  • Randomized controlled trials
  • Risk factors

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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