TY - JOUR
T1 - Repeated suppression of lymphocyte blastogenesis following vaccinations of CPV-immune dogs with modified-live CPV vaccines
AU - Mastro, J. M.
AU - Axthelm, M.
AU - Mathes, L. E.
AU - Krakowka, S.
AU - Ladiges, W.
AU - Olsen, R. G.
N1 - Funding Information:
Monoclonal antibody 7.2 was provided by Dr. P. Mastin, Puget Sound Blood Center. Supported in part by the State of Ohio Canine Research Fund.
PY - 1986/9
Y1 - 1986/9
N2 - A commercially available modified-live canine parvovirus (CPV) vaccine was evaluated for its immunosuppressive properties in eight random-bred dogs, all with circulatory antibody to CPV. Three of the eight dogs exhibited a significant decrease in lymphocyte blastogenesis after vaccine administration. In these dogs, this decrease in blastogenesis was of short duration and was consistently observed after repeated administrations of the vaccine. Neither gastroenteritis, fever nor leukopenia, signs indicative of virulent canine parvovirus infection, were detected in these animals. In addition, lymphocytes from these dogs lacked Ia antigen expression. This study demonstrated that the immunomodulating effects of ML-CPV is not observed in all animals yet is consistent in affected individuals.
AB - A commercially available modified-live canine parvovirus (CPV) vaccine was evaluated for its immunosuppressive properties in eight random-bred dogs, all with circulatory antibody to CPV. Three of the eight dogs exhibited a significant decrease in lymphocyte blastogenesis after vaccine administration. In these dogs, this decrease in blastogenesis was of short duration and was consistently observed after repeated administrations of the vaccine. Neither gastroenteritis, fever nor leukopenia, signs indicative of virulent canine parvovirus infection, were detected in these animals. In addition, lymphocytes from these dogs lacked Ia antigen expression. This study demonstrated that the immunomodulating effects of ML-CPV is not observed in all animals yet is consistent in affected individuals.
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U2 - 10.1016/0378-1135(86)90049-0
DO - 10.1016/0378-1135(86)90049-0
M3 - Article
C2 - 3776091
AN - SCOPUS:0022552108
SN - 0378-1135
VL - 12
SP - 201
EP - 211
JO - Veterinary Microbiology
JF - Veterinary Microbiology
IS - 3
ER -