Response to Comment on "Tumor-initiating cells establish an IL-33-TGF-p niche signaling loop to promote cancer progression"

Sachiko Taniguchi; Ajit Elhance; Avery van Duzer; Sushil Kumar; Justin Leitenberger; Naoki Oshimori

doi:10.1126/science.abf3316

Response to Comment on "Tumor-initiating cells establish an IL-33-TGF-p niche signaling loop to promote cancer progression"

Sachiko Taniguchi, Ajit Elhance, Avery van Duzer, Sushil Kumar, Justin Leitenberger, Naoki Oshimori

Research output: Contribution to journal › Short survey › peer-review

1 Scopus citations

Abstract

Kamphuis etal. argue that macrophages accumulated in the proximity of tumor-initiating cells do not express the high-affinity immunoglobulin E receptor FceRla. Although we cannot exclude the possibility of nonspecific binding of anti-FcεRIα antibody (clone MAR-1), we provide evidence that macrophages in squamous cell carcinomas express FceRla and that IL-33 induces FcεRlα expression in bone marrow cell-derived macrophages.

Original language	English (US)
Journal	Science
Volume	372
Issue number	6538
DOIs	https://doi.org/10.1126/science.abf3316
State	Published - Apr 9 2021

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title = "Response to Comment on {"}Tumor-initiating cells establish an IL-33-TGF-p niche signaling loop to promote cancer progression{"}",

abstract = "Kamphuis etal. argue that macrophages accumulated in the proximity of tumor-initiating cells do not express the high-affinity immunoglobulin E receptor FceRla. Although we cannot exclude the possibility of nonspecific binding of anti-FcεRIα antibody (clone MAR-1), we provide evidence that macrophages in squamous cell carcinomas express FceRla and that IL-33 induces FcεRlα expression in bone marrow cell-derived macrophages.",

author = "Sachiko Taniguchi and Ajit Elhance and {van Duzer}, Avery and Sushil Kumar and Justin Leitenberger and Naoki Oshimori",

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T1 - Response to Comment on "Tumor-initiating cells establish an IL-33-TGF-p niche signaling loop to promote cancer progression"

AU - Taniguchi, Sachiko

AU - Elhance, Ajit

AU - van Duzer, Avery

AU - Kumar, Sushil

AU - Leitenberger, Justin

AU - Oshimori, Naoki

PY - 2021/4/9

Y1 - 2021/4/9

N2 - Kamphuis etal. argue that macrophages accumulated in the proximity of tumor-initiating cells do not express the high-affinity immunoglobulin E receptor FceRla. Although we cannot exclude the possibility of nonspecific binding of anti-FcεRIα antibody (clone MAR-1), we provide evidence that macrophages in squamous cell carcinomas express FceRla and that IL-33 induces FcεRlα expression in bone marrow cell-derived macrophages.

AB - Kamphuis etal. argue that macrophages accumulated in the proximity of tumor-initiating cells do not express the high-affinity immunoglobulin E receptor FceRla. Although we cannot exclude the possibility of nonspecific binding of anti-FcεRIα antibody (clone MAR-1), we provide evidence that macrophages in squamous cell carcinomas express FceRla and that IL-33 induces FcεRlα expression in bone marrow cell-derived macrophages.

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U2 - 10.1126/science.abf3316

DO - 10.1126/science.abf3316

M3 - Short survey

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VL - 372

JO - Science

JF - Science

IS - 6538

ER -

Response to Comment on "Tumor-initiating cells establish an IL-33-TGF-p niche signaling loop to promote cancer progression"

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