Responses of cultured adult monkey trigeminal ganglion neurons to capsaicin

Susan L. Ingram; Melissa E. Martenson; Thomas K. Baumann

doi:10.1097/00001756-199304000-00032

Responses of cultured adult monkey trigeminal ganglion neurons to capsaicin

Susan L. Ingram, Melissa E. Martenson, Thomas K. Baumann

Neurosurgery

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

The sensitivity of adult primate (Macaca mulatto) trigeminal ganglion neurons to capsaicin was studied using whole-cell recording techniques. Neurons responding to capsaicin (9 out of 14) generated inward currents of up to 3.0 nA (median = 0.23 nA; interquartile range = 1.19 nA) upon drug application measured at — 60 mV. Capsaicin-sensitive neurons had longer action potential (AP) durations than capsaicin-insensitive neurons.

Original language	English (US)
Pages (from-to)	460-462
Number of pages	3
Journal	NeuroReport
Volume	4
Issue number	4
DOIs	https://doi.org/10.1097/00001756-199304000-00032
State	Published - Apr 1993

Keywords

Action potential
Capsaicin
Chemosensitivity
Irritant
Macaca mulatta
Pain
Patch clamp
Trigeminal ganglion

ASJC Scopus subject areas

General Neuroscience

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10.1097/00001756-199304000-00032

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abstract = "The sensitivity of adult primate (Macaca mulatto) trigeminal ganglion neurons to capsaicin was studied using whole-cell recording techniques. Neurons responding to capsaicin (9 out of 14) generated inward currents of up to 3.0 nA (median = 0.23 nA; interquartile range = 1.19 nA) upon drug application measured at — 60 mV. Capsaicin-sensitive neurons had longer action potential (AP) durations than capsaicin-insensitive neurons.",

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AU - Martenson, Melissa E.

AU - Baumann, Thomas K.

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N2 - The sensitivity of adult primate (Macaca mulatto) trigeminal ganglion neurons to capsaicin was studied using whole-cell recording techniques. Neurons responding to capsaicin (9 out of 14) generated inward currents of up to 3.0 nA (median = 0.23 nA; interquartile range = 1.19 nA) upon drug application measured at — 60 mV. Capsaicin-sensitive neurons had longer action potential (AP) durations than capsaicin-insensitive neurons.

AB - The sensitivity of adult primate (Macaca mulatto) trigeminal ganglion neurons to capsaicin was studied using whole-cell recording techniques. Neurons responding to capsaicin (9 out of 14) generated inward currents of up to 3.0 nA (median = 0.23 nA; interquartile range = 1.19 nA) upon drug application measured at — 60 mV. Capsaicin-sensitive neurons had longer action potential (AP) durations than capsaicin-insensitive neurons.

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KW - Capsaicin

KW - Chemosensitivity

KW - Irritant

KW - Macaca mulatta

KW - Pain

KW - Patch clamp

KW - Trigeminal ganglion

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Responses of cultured adult monkey trigeminal ganglion neurons to capsaicin

Abstract

Keywords

ASJC Scopus subject areas

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