Responsive neurostimulation is a relatively new treatment modality for refractory focal epilepsy, indicated for patients who have failed two or more seizure medications and have one or two well-localized epileptogenic foci. The RNS System is the first closed-loop neurostimulation device, which detects epileptiform activity, stores electrocorticography samples, and stimulates in response to detections. Class I evidence for its efficacy came from a randomized controlled trial that demonstrated a significant reduction in seizure frequency in the treatment arm. Subsequent studies show increasing benefit over time, with improved quality-of-life scores and no significant worsening of cognition or mood.
|Original language||English (US)|
|Title of host publication||Functional Neurosurgery and Neuromodulation|
|Number of pages||6|
|State||Published - Jan 1 2018|
- Refractory focal epilepsy
- Responsive neurostimulation
ASJC Scopus subject areas