Responsive neurostimulation

Research output: Chapter in Book/Report/Conference proceedingChapter


Responsive neurostimulation is a relatively new treatment modality for refractory focal epilepsy, indicated for patients who have failed two or more seizure medications and have one or two well-localized epileptogenic foci. The RNS System is the first closed-loop neurostimulation device, which detects epileptiform activity, stores electrocorticography samples, and stimulates in response to detections. Class I evidence for its efficacy came from a randomized controlled trial that demonstrated a significant reduction in seizure frequency in the treatment arm. Subsequent studies show increasing benefit over time, with improved quality-of-life scores and no significant worsening of cognition or mood.

Original languageEnglish (US)
Title of host publicationFunctional Neurosurgery and Neuromodulation
Number of pages6
ISBN (Electronic)9780323485692
ISBN (Print)9780323496100
StatePublished - Jan 1 2018


  • RNS
  • Refractory focal epilepsy
  • Responsive neurostimulation

ASJC Scopus subject areas

  • Medicine(all)


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