TY - JOUR
T1 - Resting Metabolic Rate, Total Daily Energy Expenditure, and Metabolic Adaptation 6 Months and 24 Months After Bariatric Surgery
AU - Wolfe, Bruce M.
AU - Schoeller, Dale A.
AU - McCrady-Spitzer, Shelly K.
AU - Thomas, Diana M.
AU - Sorenson, Chad E.
AU - Levine, James A.
N1 - Funding Information:
See Commentary, pg. 790. Funding agencies: This work was supported by a grant from the National Institutes of Health, USA (U01-DK66555 Oregon Health & Science University and DK 72479 Mayo Clinic). Disclosure: The authors declared no conflict of interest. Author contributions: BMW, DAS, and JAL conceived the study. CES carried out the clinical study. DAS, DMT, BMW, SKMS, CES, and JAL analyzed data. JAL wrote the first draft of the manuscript, and all the authors were then involved in writing the paper and approved the submitted version. JAL is the guarantor of this work and, as such, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Received: 12 September 2017; Accepted: 19 January 2018; Published online 31 March 2018. doi:10.1002/oby.22138
Funding Information:
We thank the volunteers and the staff of the Oregon Health & Science University Clinical Research Center.
Publisher Copyright:
© 2018 The Obesity Society
PY - 2018/5
Y1 - 2018/5
N2 - Objective: Little is known about long-term metabolic (energy expenditure) adaptation after bariatric surgery. Methods: Resting metabolic rate under basal conditions (RMR), total daily energy expenditure (TDEE), and body composition were measured in 25 participants in the Longitudinal Assessment of Bariatric Surgery-2. Results: Six months after surgery, BMI (±SD) decreased (47 ± 6 kg/m2 to 37 ± 5 kg/m2), body fat went from 48% ± 6% to 40% ± 6% fat, and fat-free mass went from 67 ± 9 kg to 60 ± 9 kg. In absolute terms, RMR and TDEE both decreased significantly (1,730 ± 278 kcal/d vs. 1,430 ± 200 kcal/d and 2,879 ± 544 kcal/d vs. 2,369 ± 304 kcal/d), and the achieved energy balance was −1,293 ± 355 kcal/d. Sixteen of these participants underwent repeated measures at ∼24 months; TDEE decreased 6 months postoperatively (2,957 ± 540 kcal/d to 2,423 ± 324 kcal/d; P = 0.0003), but at ∼24 months, TDEE (2,602 ± 471 kcal/d) was not significantly different compared with month 6. The average negative energy balance from baseline to month 24 was −379 ± 131 kcal/d. Conclusions: RMR and TDEE fall precipitously in the first 6 months after bariatric surgery, but these adaptive changes were no longer significant after 2 years.
AB - Objective: Little is known about long-term metabolic (energy expenditure) adaptation after bariatric surgery. Methods: Resting metabolic rate under basal conditions (RMR), total daily energy expenditure (TDEE), and body composition were measured in 25 participants in the Longitudinal Assessment of Bariatric Surgery-2. Results: Six months after surgery, BMI (±SD) decreased (47 ± 6 kg/m2 to 37 ± 5 kg/m2), body fat went from 48% ± 6% to 40% ± 6% fat, and fat-free mass went from 67 ± 9 kg to 60 ± 9 kg. In absolute terms, RMR and TDEE both decreased significantly (1,730 ± 278 kcal/d vs. 1,430 ± 200 kcal/d and 2,879 ± 544 kcal/d vs. 2,369 ± 304 kcal/d), and the achieved energy balance was −1,293 ± 355 kcal/d. Sixteen of these participants underwent repeated measures at ∼24 months; TDEE decreased 6 months postoperatively (2,957 ± 540 kcal/d to 2,423 ± 324 kcal/d; P = 0.0003), but at ∼24 months, TDEE (2,602 ± 471 kcal/d) was not significantly different compared with month 6. The average negative energy balance from baseline to month 24 was −379 ± 131 kcal/d. Conclusions: RMR and TDEE fall precipitously in the first 6 months after bariatric surgery, but these adaptive changes were no longer significant after 2 years.
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U2 - 10.1002/oby.22138
DO - 10.1002/oby.22138
M3 - Article
C2 - 29604193
AN - SCOPUS:85045724865
SN - 1930-7381
VL - 26
SP - 862
EP - 868
JO - Obesity
JF - Obesity
IS - 5
ER -